Nuclear SMAD5 dances to a different tune in regulating insulin secretion

In this issue of Cell Metabolism, Fang et al. 1 Fang Y. Feng H. Zhang B. Zhang S. Zhou Y. Hao P. Zhou Z. Zhou S. Li N. Hui Y. et al. Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic beta cells. Cell Metab. 2024; 36: 1237-1251.e4https://doi.org/10.1016/j.cmet.2024.02.012 Abstract Full Text Full Text PDF Scopus (1) Google Scholar report a novel pH-sensitive cellular signaling mechanism involving the transcription factor SMAD5 that regulates the vesicular secretion of insulin from pancreatic β cells in response to dietary challenges. Dysregulation of this pathway may contribute to metabolic disorders such as type 2 diabetes mellitus. In this issue of Cell Metabolism, Fang et al. 1 Fang Y. Feng H. Zhang B. Zhang S. Zhou Y. Hao P. Zhou Z. Zhou S. Li N. Hui Y. et al. Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic beta cells. Cell Metab. 2024; 36: 1237-1251.e4https://doi.org/10.1016/j.cmet.2024.02.012 Abstract Full Text Full Text PDF Scopus (1) Google Scholar report a novel pH-sensitive cellular signaling mechanism involving the transcription factor SMAD5 that regulates the vesicular secretion of insulin from pancreatic β cells in response to dietary challenges. Dysregulation of this pathway may contribute to metabolic disorders such as type 2 diabetes mellitus.