硫化氢
材料科学
充氧
缺氧(环境)
癌症研究
硫化物
肿瘤缺氧
氧气
医学
有机化学
内科学
硫黄
化学
冶金
放射治疗
作者
Qi Yu,Qin Zhang,Yujing Zhou,Shan Yan,Juan Li,Yang Ce-yao,Jie Xu,Li Cao,Chao Zhang,Yao Sun
标识
DOI:10.1002/adfm.202419386
摘要
Abstract Oxygen (O 2 ) tension within a tumor is considered a hallmark of sonodynamic therapy (SDT). Herein, multifunctional nanoregulators, CMCS‐Au‐SrS (CAS), are reported, which are assembled by carboxymethyl chitosan(CMCS) tethered gold nanoclusters (Au NCs) as sonosensitizers and sulfurate donors strontium sulfide nanoparticles (SrS NPs), to evoke selective SDT in hypoxic tumors. CAS possess tumor‐acidity responsiveness to form large‐size aggregated Au NCs with shortened bandgap so that effectively induce powerful reactive oxygen species generation. On the other hand, acidity triggers the degradation of SrS NPs and release hydrogen sulfide (H 2 S), evoking tumor oxygenation to overcome hypoxia. This in junction with the accelerated sonosensiting ability boosts amplified SDT efficacy. More importantly, specific glycolysis induced acidification leads to CAS selectively accumulated in cancer cells, further guaranteeing the execution of the advanced therapeutic manners. Additionally, doping Nd 3+ in SrS NPs endows CAS with the second near‐infrared fluorescence to facilitate the in vivo tracing property with good tissue penetration (up to 6 mm). This strategy may play a pioneering role to develop theranostic reagents with improved tumor enrichment capacity and enhanced SDT in hypoxia tumors.
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