Increased interaction between B cells and CD3+ T cells in non-progressors with human papillomavirus-associated oropharyngeal squamous cell carcinoma

免疫系统 CD8型 淋巴结 间质细胞 细胞毒性T细胞 T细胞 生物 细胞 癌症研究 免疫学 病理 医学 体外 生物化学 遗传学
作者
Kathleen R. Bartemes,Raymond M. Moore,Brenna C Novotny,Kevin D. Pavelko,William H. Sherman,Michael Rivera,Joaquín J. García,Linda X. Yin,J. Daniel,Eric J. Moore,Kathryn M. Van Abel,David M. Routman
出处
期刊:Clinical Cancer Research [American Association for Cancer Research]
被引量:1
标识
DOI:10.1158/1078-0432.ccr-24-2425
摘要

Abstract Background: Tumor-infiltrating lymphocytes (TILs) are associated with decreased risk of recurrence in human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV(+)OPSCC). The composition and spatial distribution of TILs and tumor-infiltrating immune cells is not well characterized. Methods: Formalin-fixed paraffin-embedded primary and lymph node (LN) tumor tissues from ten progressors (cases) and ten matched non-progressors (controls) were interrogated by imaging mass cytometry. Immune, stromal, and tumor cells were quantified from selected regions of interest (ROIs) using machine learning. Nearest neighbors, cell-cell interactions, and niche analyses were performed. Results: In primary ROIs, immune cell, lymphocyte, T cell, CD8+ T cell, and innate cell prevalence was significantly greater in controls. High prevalence of immune cells, lymphocytes, innate cells, and CD4+ T cells in primary tissues was significantly associated with increased time to event (TTE). Although primary and LN prevalence of T cells, CD4+ T cells, CD8+ T cells, macrophages, and tumor cells were significantly correlated, differences in LNs were neither significant nor associated with TTE. Average distances between T cells and nearest B cells, and between lymphocytes and nearest tumor cells were decreased in control primary tissues. Interactions between B cells and T cells were less organized in primary tissues from cases. A niche predominantly comprising lymphocytes was associated with longer TTE. Conclusion: In HPV(+)OPSCC, immune cell subset prevalence in primary tumors differs with outcome and is associated with TTE. Interactions between B cells and both T cell subsets are associated with longer TTE, underscoring the importance of active intratumoral immune responses in outcomes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小马甲应助mr.pork采纳,获得10
刚刚
清新的小懒猪完成签到,获得积分10
1秒前
酷波er应助科研通管家采纳,获得10
1秒前
1秒前
充电宝应助科研通管家采纳,获得10
1秒前
情怀应助科研通管家采纳,获得10
2秒前
科研通AI5应助科研通管家采纳,获得10
2秒前
逆时针应助科研通管家采纳,获得10
2秒前
Owen应助科研通管家采纳,获得50
2秒前
CipherSage应助科研通管家采纳,获得10
2秒前
圆锥香蕉应助科研通管家采纳,获得20
2秒前
乐乐应助科研通管家采纳,获得10
2秒前
天天快乐应助科研通管家采纳,获得10
2秒前
2秒前
圆锥香蕉应助科研通管家采纳,获得20
2秒前
2秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
qsy发布了新的文献求助10
4秒前
懵懂的半蕾完成签到,获得积分10
4秒前
Fengliguantou发布了新的文献求助30
4秒前
xunxunmimi完成签到,获得积分10
4秒前
5秒前
科目三应助乐观紫采纳,获得10
6秒前
我是小短腿的妹妹完成签到,获得积分20
7秒前
lily完成签到,获得积分10
7秒前
感谢有你发布了新的文献求助10
9秒前
wh2740完成签到,获得积分10
10秒前
SHAO应助可乐冰淇淋采纳,获得30
13秒前
13秒前
脑洞疼应助JUdy采纳,获得10
15秒前
何白发布了新的文献求助10
15秒前
Lu发布了新的文献求助10
16秒前
hugdoggy完成签到,获得积分10
18秒前
18秒前
桃子发布了新的文献求助30
21秒前
22秒前
Liufgui给风之星的求助进行了留言
22秒前
23秒前
Lucas应助桔子采纳,获得30
25秒前
JUdy发布了新的文献求助10
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105