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Increased interaction between B cells and CD3+ T cells in non-progressors with human papillomavirus-associated oropharyngeal squamous cell carcinoma

免疫系统 CD8型 淋巴结 间质细胞 细胞毒性T细胞 T细胞 生物 细胞 癌症研究 免疫学 病理 医学 体外 生物化学 遗传学
作者
Kathleen R. Bartemes,Raymond M. Moore,Brenna C Novotny,Kevin D. Pavelko,William H. Sherman,Michael Rivera,Joaquín J. García,Linda X. Yin,J. Daniel,Eric J. Moore,Kathryn M. Van Abel,David M. Routman
出处
期刊:Clinical Cancer Research [American Association for Cancer Research]
被引量:1
标识
DOI:10.1158/1078-0432.ccr-24-2425
摘要

Abstract Background: Tumor-infiltrating lymphocytes (TILs) are associated with decreased risk of recurrence in human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV(+)OPSCC). The composition and spatial distribution of TILs and tumor-infiltrating immune cells is not well characterized. Methods: Formalin-fixed paraffin-embedded primary and lymph node (LN) tumor tissues from ten progressors (cases) and ten matched non-progressors (controls) were interrogated by imaging mass cytometry. Immune, stromal, and tumor cells were quantified from selected regions of interest (ROIs) using machine learning. Nearest neighbors, cell-cell interactions, and niche analyses were performed. Results: In primary ROIs, immune cell, lymphocyte, T cell, CD8+ T cell, and innate cell prevalence was significantly greater in controls. High prevalence of immune cells, lymphocytes, innate cells, and CD4+ T cells in primary tissues was significantly associated with increased time to event (TTE). Although primary and LN prevalence of T cells, CD4+ T cells, CD8+ T cells, macrophages, and tumor cells were significantly correlated, differences in LNs were neither significant nor associated with TTE. Average distances between T cells and nearest B cells, and between lymphocytes and nearest tumor cells were decreased in control primary tissues. Interactions between B cells and T cells were less organized in primary tissues from cases. A niche predominantly comprising lymphocytes was associated with longer TTE. Conclusion: In HPV(+)OPSCC, immune cell subset prevalence in primary tumors differs with outcome and is associated with TTE. Interactions between B cells and both T cell subsets are associated with longer TTE, underscoring the importance of active intratumoral immune responses in outcomes.
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