Subacute Neurological Improvement Predicts Favorable Functional Recovery After Intracerebral Hemorrhage: INTERACT2 Study

医学脑出血改良兰金量表优势比混淆冲程（发动机）内科学可能性逻辑回归麻醉蛛网膜下腔出血缺血性中风缺血机械工程工程类

作者

Shoujiang You,Danni Zheng,Xiaoying Chen,Xia Wang,Menglu Ouyang,Qiao Han,Yongjun Cao,Candice Delcourt,Lili Song,Cheryl Carcel,Hisatomi Arima,Chun‐Feng Liu,Richard I. Lindley,Thompson Robinson,Craig S. Anderson,John Chalmers,S. Davis,E. Heeley,Yining Huang,Pablo M. Lavados,Bruce Neal,Mark Parsons,Richard I. Lindley,Lewis B. Morgenstern,Christian Stapf,Christophe Tzourio,J.G. Wang,Yining Huang,S. Chen,X.Y. Chen,Li Cui,Z. Liu,Cheng‐Kai Lu,Jing Wang,Shuo Wu,En Xu,Qing Yang,C. Zhang,J. Zhang,Ronny Beer,Erich Schmutzhard,P. Redondo,Markku Kaste,Lauri Soinne,Turgut Tatlisumak,Christian Stapf,Katja E. Wartenberg,Stefano Ricci,K. Klijn,Elsa Azevedo,Ángel Chamorro,Marilyn Arnold,Urs Fischer,Sanjiv Kaul,Jeyaraj Pandian,H. Boyini,Sally Singh,Alejandro A. Rabinstein,Conrado J. Estol,Pablo M. Lavados,Verónica V. Olavarría,Thompson Robinson,John Simes,M.-G. Bousser,Graeme J. Hankey,Konrad Jamrozik,Claiborne Johnston,Shiyong Li,E. Heeley,K. Bailey,Johnny T. K. Cheung,S. Chintapatla,Éric Ducasse,T. Erho,Jun Hata,B. Holder,E. Knight,Richard I. Lindley,Michele LeRoux,T. Sassé,E. Odgers,R. C. Walsh,Z. Wolfowicz,Guofeng Chen,Stephanie Fuentes,Richard I. Lindley,Bin Peng,H Schneble,M.-X. Wang,Laurent Billot,Stéphane Héritier,Q. Li,Mark Woodward,Ṣẹ̀yẹ Abímbọ́lá,Simon Anderson,E. Chan,Gang Cheng,P. Chmielnik,Jun Hata,S. Leighton,J.-Y. Liu,Bodil Steen Rasmussen,Anitá Saxena,Sudeshna Tripathy,M. Armenis,M. A. Baig,B. Naidu,G. Starzec,S. Steley,E. Heeley,Michele LeRoux,T. Sassé,E. Knight,K. Bailey,Johnny T. K. Cheung,E. Odgers,Éric Ducasse,B. Holder,Z. Wolfowicz,R. C. Walsh,S. Chintapatla,T. Erho,Conrado J. Estol,Anna Moles,Alfredo Bardajı́,Martina Zimmermann,J. Marinho,S. Alves,R. Angelim,J. Araujo,L. Kawakami,Pablo M. Lavados,Verónica V. Olavarría,C. Bustos,Fernando Rodríguez González,Paula Muñoz Venturelli,Yining Huang,Xiaoying Chen,Yining Huang,Ran Jia,Nan Li,Shanshan Qu,Y. Shu,Alexandra Song,Jianbin Sun,Jiayu Xiao,Yang Zhao,Jiangfeng Wang,Qiu-Sha Huang,Christian Stapf,Éric Vicaut,A. Chamam,M.-C. Viaud,C. Dert,U. Fiedler,V. Jovis,S. Kabla,Serge Marchand,Alfonso de la Peña,V. Rochaud,Mallikarjuna Kandalam,H. Boyini,N. Hasan,Eivind Berge,Else Charlotte Sandset,A. S. Forårsveen,D. Richardson,T. Kumar,Shlomo Lewin,HM Dewey,Laura Walker,S. Petrolo,C. Bladin,Jonathon Sturm,Denis Crimmins,Denise Griffiths,Alexander Schütz,V. Zenteno,Mark Parsons,Ferdinand Miteff,Neil J. Spratt,E. Kerr,Christopher Levi,Thanh G. Phan,Henry Ma,L. Sanders,Chris Moran,Kam Cheong Wong,Stephen Read,Robin Henderson,Aaron Wong,R. Hull,G. Skinner,S. Davis,Peter J. Hand,Brian Yan,H. Tu,Benjamin R. Campbell,David Blacker,Western Hospital,Tissa Wijeratne,Manoji Pathirage,M. Jasinararchchi,Zelko Matkovic,Sherisse Celestino,F. Gruber,Milan R. Voško,E. Diabl,S. Rathmaier,Ronny Beer,Erich Schmutzhard,Bettina Pfausler,Raimund Helbok,Franz Fazekas,Urs Fischer,Birgit Poltrum,B. Zechner,U. Trummer,Matthieu Pierre Rutgers,André Peeters,Anne Dusart,Mehmet Duray,C. Parmentier,Susana Ferrão Santos,Raf Brouns,Sylvie De Raedt,Ann De Smedt,R.-J. Van Hooff,Jacques De Keyser,Sheila Cristina Ouriques Martins,A.G. de Almeida,R. Broudani,N.F. Titton,Gabriel R. de Freitas,F.M. Cardoso,Louise Giesel,N.A. Lima,A.C. Ferraz de Almeida,Régis Gomes,T.S. Borges dos Santos,E.M. Veloso Soares,Osório Lopes Abath Neto,G.S. Silva,D. Gomes,F.A. de Carvalho,M. Miranda,A. Marques,Viviane Flumignan Zétola,G. de Matia,Marcos Christiano Lange,Jacqueline Montes,A. Reccius,Paula Muñoz Venturelli,Verónica V. Olavarría,Ana Belén García Soto,Rodrigo Rivas,C Klapp,Sergio Illanes,Carlos Aguilera,A. Castro,C. Figueroa,Jhonattan Benavides,P. Salamanca,Mauricio Concha,J. Pajarito,P. Araya,Federico Guerra,Yan Li,G. Liu,B. Wang,J. Zhang,Yong Chong,Mosso He,Longsheng Wang,J. Liu,Xiaolei Zhang,Chung‐Yu Lai,He Jiang,Qing Yang,Sophia Cui,Q. Tao,Y. Zhang,S. Yao,Ming Xu,Y. Zhang,Z. Liu,Han Xiao,Jin Hu,Jessica Tang,Jianbin Sun,H. Ji,M. Jiang,F. Yu,Y. Zhang,Xiangdong Yang,Xiaohong Guo,Yi Wang,Longfei Wu,Z. Liu,Yajie Gao,Dong Sun,Xiaoting Huang,Yi Wang,L. Liu,Yan Li,Ping Li,Yi Jiang,Hezong Li,Hung‐I Lu,Junshan Zhou,C. Yuan,Xun Qi,Feng Qiu,Haiyan Qian,W. Wang,J. Liu,Yining Huang,Wen Sun,Fei Li,R. Liu,Qiang Peng,Z. Ren,Chao Fan,Y. Zhang,Hui‐Tian Wang,T. Wang,Fu‐Dong Shi,Chen Duan,S. Chen,Jing Wang,Z. Chen,Xuerui Tan,Z. Zhao,Yajie Gao,J. Chen,Tao Han,Shuo Wu,Lixin Zhang,Longsheng Wang,HU Qing,Qing Hou,Xin Zhao,Longsheng Wang,G. Zeng,Lu Ma,F. Wang,S. Chen,Li Zeng,Zhigang Guo,Yu Fu,Yang Song,L. Tai,X. Liu,X. Su,Jean Yang,Rong Dong,Yiting Xu,Sai Tian,Shasha Cheng,Li Su,Xuewei Xie,Tan Xu,Deqin Geng,Xiao Yan,Huimin Fan,Naisi Zhao,Shuguang Wang,Jean Yang,J. Zhang,Min Yan,Linxin Li,Z. Li,Xiao Yun Xu,F. Wang,Longfei Wu,Xiaohong Guo,Ying Lian,H. Sun,D. Liu,N. Wang,Q. Tang,Zhi‐Yan Han,Feng Lin,Y. Cui,Jiwei Tian,Hsing‐Yi Chang,Xiangying Sun,Jing Wang,Chao Liu,Zheng Wen,En Xu,Qiang Li,Xiaolei Zhang,Lina Sun,Bo Hu,Mengchen Zou,Qiligeer Bao,X. Lin,Liming Zhao,X. Tian,Hui‐Tian Wang,Xia Wang,Xianchan Li,Li-dan Hao,Yunyou Duan,R. Wang,Zilong Wei,J. Liu,S. Ren,Hongqi Ren,Yi Wang,Dong Yan,Yali Cheng,Mengchen Zou,Wei Wei Liu,J. Han,C. Zhang,Zheng Zhang,J. Zhu,Yi Wang,Q. Li,Jun Qian,Yingxian Sun,Kuo Liu,Faqing Long,Xiaofei Peng,Qilu Zhang,Zong-Li Yuan,Chun Wang,Minqiang Huang,J. Zhang,F. Wang,Panpan He,Yeon Ho You,Xia Wang,Qing Yang,Hui‐Tian Wang,Jun Xia,Qianzhou Lv,Yinglong Hou,Yi Wang,L. Liu,Y. Qi,Ling Mei,R. Lu,Guofeng Chen,L. Liu,Ping Li,Wei Wei Liu,Shuyu Zhou,Jing Wang,Longsheng Wang,Hezong Li,S. Zhang,Longsheng Wang,Runmei Zou,Jiang Guo,M. Li,W. Wei,Lauri Soinne,Sami Curtze,Maria Saarela,Daniel Strbian,Filip Scheperjans,T. de Broucker,Christopher Henry,R. Cumurciuc,N. Ibos-Augé,Anne-Céline Zeghoudi,Francisco Picó,Olivier Dereeper,Marina Simian,Clément Boisselier,A. Mahfoud,Serge Timsit,F.-M. Merrien,B. Guillon,M. Sevin,Fanny Hérisson,C. Magne,Abdol A. Ameri,C. Cret,S. Stefanizzi,F. Klapzcynski,Christian Denier,M. Sarov-Rivière,Christian Stapf,Peggy Reiner,Jérôme Mawet,Dominique Hervé,F. Buffon,Emmanuel Touzé,V. Domigo,Chantal Lamy,D. Calvet,M. Pasquini,Sonia Alamowitch,Pascal Favrole,I.-P. Muresan,Sophie Crozier,Charlotte Rosso,C. Pirès,Anne Léger,S. Deltour,Charlotte Cordonnier,Hilde Hénon,Costanza Rossi,Mohammad Zuber,Marie Bruandet,Ruben Tamazyan,Claire Join-Lambert,Eric Jüettler,Trudy Millard Krause,S. Maul,Matthias Endres,Gerhard J. Jungehülsing,M. Hennerici,Martin Griebe,Tamara Sauer,K. Knoll,R. Huber,K. Knauer,C. Michael Knauer,S. Raubold,H. Schneider,H. Hentschel,C. Lautenschläger,Eik Schimmel,Imanuel Dzialowski,Christian Foerch,Matthias Lorenz,O.C. Singer,Igor Martins Santos,A. Hartmann,A. Hamann,Alexander Schacht,Bruce J. Schrader,A. Teíchmann,Katja E. Wartenberg,Thomas J. J. Mueller,Sławomir Jander,Michael Gliem,Claudia Boettcher,Michael Rosenkranz,Cynthia A Beck,Dörte Otto,Götz Thomalla,Bastian Cheng,Kam Sing Wong,Thomas Leung,Y.O.Y. Soo,S. Prabhakar,S.R. Kesavarapu,P.K. Gajjela,Chenna Ramu,K. Ummer,Maamoun Basheer,A. Andipet,M.K.M. Jagarlapudi,Ashfaq Mohammed,Vishwajeet Pawar,S.S.K. Eranki,Jeyaraj Pandian,Y. Singh,Nasim Akhtar,GNRC Hospitals,Nomal Chandra Borah,M. Ghose,Nusrat Choudhury,N.R. Ichaporia,J. Shendge,S. Khese,Vijaya Pamidimukkala,P. Inbamuthaiah,Sushma Nuthakki,N.M.R. Tagallamudi,A.K. Gutti,Dheeraj Khurana,P. Kesavarapu,V. Jogi,Amita Garg,Damayanti Samanta,G.R.K. Sarma,Raghunandan Nadig,Thomas Mathew,M.A. Anandan,E. Caterbi,Andrea Zini,Milena Cavazzuti,Federica Casoni,Roberta Pentore,Francesca Maria Antonella Falzone,Stefano Ricci,Tatiana Mazzoli,Lisa Greco,C. Menichetti,Francesca Coppola,Silvia Cenciarelli,E. Gallinella,A. Mattioni,R Condurso,I. Sicilia,Mauro Zampolini,Francesco Corea,Mali Barbi,Costanza Proietti,Danilo Toni,A. Pieroni,A. Anzini,Anne Falcou,M. Demichele,Catharina J.M. Klijn,Arnstein Tveiten,Erik Thomas Thortveit,S. Pettersen,N. Holand,B. Hitland,Stein Harald Johnsen,Agnethe Eltoft,Mohammad Wasay,Arshad Kamal,Ambreen Iqrar,Latisha K. Ali,Dil Begum,G. Gama,Elsa Azevedo,L. Fonseca,G. Moreira,L.M. Veloso,Diego Pinheiro,Laura Gallego Paredes,C. Rozeira,Tiago Gregório,Tomás Segura,Ó. Ayo,Javier Garcı́a-Garcı́a,Inmaculada Feria-Vilar,I. Gómez Fernández,Ángel Chamorro,Sergio Amaro,Xabier Urra,Vı́ctor Obach,Álvaro Cervera,Yolanda Silva,Joaquı́n Serena,Mar Castellanos,Mikel Terceño,Cecile van Eendenburg,Urs Fischer,Marilyn Arnold,Anja Weck,Oliver Findling,R. Lüdi,Elizabeth A. Warburton,Diana J. Day,N. Butler,E. Bumanlag,S. Caine,A. Steele,Michael J. Osborn,Erin Dodd,Patrick Murphy,Bernard Esisi,Eli M. Brown,R. Hayman,V. K.V. Baliga,M. Minphone,J. Kennedy,Ian Reckless,George Pope,Rachel Teal,K. Michael,Dulka Manawadu,Lalit Kalra,R. Lewis,B. Mistry,E. Cattermole,A. Hassan,L. Mandizvidza,John Bamford,H. L. Brooks,C. Bedford,R.L. Whiting,Paul Baines,M. Hussain,Mark Harvey,K. Fotherby,Scott McBride,Paula Bourke,D. Morgan,Karla Jennings-Preece,Christopher Price,S. Huntley,V.E. Riddell,G. Storey,Rachel Lakey,G. Subramanian,Damian Jenkinson,Joseph Kwan,Olivier David,D. Tiwari,Martin James,Sharon Keenan,H. Eastwood,Linda Shaw,Philip Kaye,D. Button,B. Madigan,D. Williamson,A. Dixit,Joshua S. Davis,M.O. Hossain,Gary A. Ford,Adrian Parry‐Jones,V. O'Loughlin,R. Jarapa,Zin Naing,Caroline Lovelock,John O’Reilly,Ubaid Khan,Aneil Bhalla,A. G. Rudd,Jonathan Birns,David J. Werring,Ryan Law,Richard Perry,I. Jones,Renuka Erande,Christine Roffe,Indira Natarajan,Naveed Ahmad,K. Finney,J. Lucas,Amit Mistri,David Eveson,Reginald Marsh,Victoria J. Haunton,Alejandro A. Rabinstein,Jennifer Fugate,S. Lepore

出处

期刊：Stroke [Ovid Technologies (Wolters Kluwer)]
日期：2025-02-03

链接

nih.govdoi.org

标识

DOI：10.1161/strokeaha.124.048847

摘要

BACKGROUND: The frequency and prognostic significance of subacute neurological improvement (SNI) on 90-day outcomes after acute intracerebral hemorrhage are unknown. METHODS: Secondary analyses of participant data from the INTERACT2 trial (second Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial). SNI included any, moderate, significant, and substantial neurological improvement defined as ≥1, ≥2, ≥3, and ≥4 points decrease, respectively, on the National Institutes of Health Stroke Scale from 24 hours to 7 days after intracerebral hemorrhage. Logistic regression models were used to assess associations of SNI and death or major disability (modified Rankin Scale score of 3–6), major disability (modified Rankin Scale scores, 3–5), and death alone at 90 days. Data are reported as odds ratios and 95% CIs. RESULTS: Of 2571 patients included in analyses, 1492 (58.0%), 1057 (41.1%), 731 (28.4%), and 490 (19.1%) patients experienced any, moderate, significant, and substantial SNI (24 hours to 7 days) after intracerebral hemorrhage, respectively. After adjustment for key confounders, any SNI was associated with 49%, 25%, and 65% reduced odds of death or major disability (odds ratio, 0.51 [95% CI, 0.42–0.63]), major disability alone (odds ratio, 0.75 [95% CI, 0.63–0.90]), and death (odds ratio, 0.35 [95% CI, 0.24–0.50]), respectively. Moderate, significant, and substantial SNI were also significantly associated with decreased odds of death or major disability at 90 days. The relationship between any SNI and study outcomes was consistent in most subgroups, including age and baseline hematoma volume. Early intensive blood pressure-lowering treatment did not increase the odds of SNI. CONCLUSIONS: SNI from 24 hours to 7 days is common after intracerebral hemorrhage and predicts a lower likelihood of death or major disability. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00716079.

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Subacute Neurological Improvement Predicts Favorable Functional Recovery After Intracerebral Hemorrhage: INTERACT2 Study

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