Alkaline etching assisted polydopamine coating for enhanced cell–material interactions on 3D printed polylactic acid scaffolds

The implant surface chemistry and topography are primary factors regulating the success and survival of bone scaffold. Surface modification is a promising alternative to enhance the biocompatibility and tissue response to augment the osteogenic functionalities of polyesters like PLA. The study employed the synergistic effect of alkaline hydrolysis and polydopamine (PDA) functionalization to enhance the cell-material interactions on 3D printed polylactic acid (PLA) scaffold. Comprehensive characterization of the modified PLA highlights the improvements in the physical, chemical and cell-material interactions upon two-step surface modification. The X-ray photoelectron spectroscopy (XPS) analysis substantiated enhanced PDA deposition with