石墨烯
检出限
化学
电化学
二氧化钛
氧化物
纳米复合材料
环境友好型
电极
化学工程
纳米技术
组合化学
色谱法
材料科学
有机化学
生态学
物理化学
工程类
生物
作者
Yangguang Zhu,Xiufen Li,Mengfan Wu,Mingjiao Shi,Qichen Tian,Li Fu,Hsu‐Sheng Tsai,Wanfeng Xie,Guosong Lai,Gang Wang,Nan Jiang,Hongzhi Wang,Cheng‐Te Lin
标识
DOI:10.1016/j.aca.2023.341607
摘要
Developing a rapid, sensitive, and efficient analytical method for the trace-level determination of highly concerning antibiotic ciprofloxacin (CIP) is desirable to guarantee the safety of human health and ecosystems. In this work, a novel electrochemical aptasensor based on polyethyleneimine grafted reduced graphene oxide and titanium dioxide (rGO/PEI/TiO2) nanocomposite was constructed for ultrasensitive and selective detection of CIP. Through the in-situ electrochemical oxidation of Ti3C2Tx nanosheets, TiO2 nanosheets with good electrochemical response were prepared in a more convenient and eco-friendly method. The prepared TiO2 nanosheets promote charge transferring on electrode interface, and [Fe(CN)6]3-/4- as electrochemical active substance can be electrostatically attracted by rGO/PEI. Thus, electrochemical detection signal of the aptasensor variates a lot after specific binding with CIP, achieving working dynamic range of 0.003–10.0 μmol L−1, low detection limit down to 0.7 nmol L−1 (S/N = 3) and selectivity towards other antibiotics. Additionally, the aptasensor exhibited good agreement with HPLC method at 95% confidence level, and achieved good recoveries (96.8–106.3%) in real water samples, demonstrating its suitable applicability of trace detection of CIP in aquatic environment.
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