化学
纳米技术
生化工程
催化作用
纳米颗粒
催化效率
组合化学
生物化学
材料科学
工程类
作者
Ruyan Fu,Wei Wang,Hongbin Zhao,Huan Yu Jin,Ya Tang,Ting He,Yaping Ding,Jiujun Zhang,Daixin Ye
出处
期刊:Analytical Chemistry
[American Chemical Society]
日期:2023-07-12
卷期号:95 (29): 10844-10858
被引量:35
标识
DOI:10.1021/acs.analchem.3c01005
摘要
Natural enzymes are crucial in biological systems and widely used in biology and medicine, but their disadvantages, such as insufficient stability and high-cost, have limited their wide application. Since Fe3O4 nanoparticles were found to show peroxidase-like activity, researchers have designed and developed a growing number of nanozymes that mimic the activity of natural enzymes. Nanozymes can compensate for the defects of natural enzymes and show higher stability with lower cost. Iron, a nontoxic and low-cost transition metal, has been used to synthesize a variety of iron-based nanozymes with unique structural and physicochemical properties to obtain different enzymes mimicking catalytic properties. In this perspective, catalytic mechanisms, activity modulation, and their recent research progress in sensing, tumor therapy, and antibacterial and anti-inflammatory applications are systematically presented. The challenges and perspectives on the development of iron-based nanozymes are also analyzed and discussed.
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