已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM2.5

竞争性内源性RNA 粘合连接 小RNA 细胞生物学 生物 表型 发病机制 化学 下调和上调 免疫学 基因 钙粘蛋白 细胞 长非编码RNA 生物化学
作者
Qingping Liu,Yaling Zhang,Bin Han,Mengruo Wang,Huaifang Hu,Jie Ning,Wentao Hu,Mei‐Yu Chen,Yaxian Pang,Yuanyuan Chen,Lei Bao,Yujie Niu,Rong Zhang
出处
期刊:Journal of Environmental Sciences-china [Elsevier]
卷期号:137: 527-539 被引量:1
标识
DOI:10.1016/j.jes.2023.02.027
摘要

As an environmental pollutant, ambient fine particulate matter (PM2.5) was linked to cardiovascular diseases. The molecular mechanisms underlying PM2.5-induced extrapulmonary disease has not been elucidated clearly. In this study the ambient PM2.5 exposure mice model we established was to explore adverse effects of vessel and potential mechanisms. Long-term PM2.5 exposure caused reduced lung function and vascular stiffness in mice. And chronic PM2.5 induced migration and epithelial-mesenchymal transition (EMT) phenotype in BEAS-2B cells. After PM2.5 treatment, the circRNAs and mRNAs levels of exosomes released by BEAS-2B cells were detected by competing endogenous RNA (ceRNA) array, which contained 1664 differentially expressed circRNAs (DE-circRNAs) and 308 differentially expressed mRNAs (DE-mRNAs). By bioinformatics analysis on host genes of DE-circRNAs, vascular diseases and some pathways related to vascular diseases including focal adhesion, tight junction and adherens junction were enriched. Then, ceRNA network was constructed, and DE-mRNAs in ceRNA network were conducted functional enrichment analysis by Ingenuity Pathway Analysis, which indicated that hsa_circ_0012627, hsa_circ_0053261 and hsa_circ_0052810 were related to vascular endothelial dysfunction. Furthermore, it was verified experimentally that ExoPM2.5 could induce endothelial dysfunction by increased endothelial permeability and decreased relaxation in vitro. In present study, we investigated in-depth knowledge into the molecule events related to PM2.5 toxicity and pathogenesis of vascular diseases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
character577完成签到,获得积分10
3秒前
6秒前
小石完成签到,获得积分10
7秒前
7秒前
向语堂发布了新的文献求助10
8秒前
uranus完成签到,获得积分10
9秒前
衣谷完成签到 ,获得积分10
9秒前
Syj2468完成签到 ,获得积分10
10秒前
LIUDEHUA发布了新的文献求助10
10秒前
Calyn完成签到 ,获得积分10
10秒前
ttxxcdx发布了新的文献求助10
10秒前
BB发布了新的文献求助10
11秒前
打工不可能完成签到,获得积分10
11秒前
WYJ完成签到,获得积分10
13秒前
研友_5Y9Z75完成签到 ,获得积分0
13秒前
13秒前
小白狗完成签到,获得积分10
14秒前
Orange应助小石采纳,获得10
14秒前
14秒前
赘婿应助科研通管家采纳,获得10
14秒前
桐桐应助科研通管家采纳,获得10
14秒前
深情安青应助科研通管家采纳,获得10
14秒前
华仔应助科研通管家采纳,获得10
14秒前
大模型应助科研通管家采纳,获得10
14秒前
14秒前
Owen应助小禾采纳,获得10
15秒前
15秒前
Zhang_Yakun完成签到 ,获得积分10
15秒前
17秒前
MaoTing完成签到,获得积分10
19秒前
华仔应助anchen采纳,获得10
20秒前
24Rabbits完成签到,获得积分10
21秒前
xh完成签到,获得积分10
21秒前
清净126完成签到 ,获得积分10
21秒前
yomi完成签到 ,获得积分10
21秒前
SciGPT应助13654135090采纳,获得10
22秒前
微笑冰棍完成签到 ,获得积分10
22秒前
布可完成签到,获得积分10
23秒前
24秒前
blossoms完成签到 ,获得积分10
24秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3200547
求助须知:如何正确求助?哪些是违规求助? 2850327
关于积分的说明 8071746
捐赠科研通 2514144
什么是DOI,文献DOI怎么找? 1346881
科研通“疑难数据库(出版商)”最低求助积分说明 640268
邀请新用户注册赠送积分活动 610386