Recent advances in the therapeutic potential of nobiletin against respiratory diseases

Nobiletin is a natural polymethoxylated flavonoid widely present in citrus fruit peels. It has been extensively studied due to its wide range of pharmacological activities and considered a potential therapeutic drug for various diseases. It has been demonstrated to exert the effects of anti-tumor, anti-inflammation, anti-oxidative, anti-apoptotic and improve cardiovascular function. Increasing evidences suggest that nobiletin plays an important role in respiratory diseases (RDs) treatment. This review aimed to investigate the therapeutic potential of nobiletin against RDs based on studies published in PubMed, Web of Science, and Scopus databases in English until June 26, 2023. We highlighted the novel findings regarding the role and mechanism of nobiletin in RDs treatment, such as lung cancer, COPD, pulmonary fibrosis, asthma, pulmonary infection, acute lung injury, coronavirus disease 2019, and pulmonary arterial hypertension. These findings suggest that nobiletin can be used as a potential agent for preventing and treating RDs.