Systemic Inflammation as the Health-Related Communication Tool Between the Human Host and Gut Microbiota in the Framework of Predictive, Preventive, and Personalized Medicine

The level of synergies between the human host and gut microbiota is frequently underestimated: growing evidence demonstrates a multi-faceted interplay influencing health status stability of the host, health-to-disease transition, disease severity grad, therapy-resistance and individual outcomes. Moreover, a powerful instrument has been established in cross-talk between the human host and gut microbiota, namely an inflammation. Therefore, a detailed understanding of mechanisms underlying systemic inflammation as the key-tool to regulate the quality and stability of cooperation between the human host and gut microbiota is crucial for cost-effective screening programs and targeted disease prevention in primary and secondary care following the principles of 3P Medicine.