Diabetic conditions promote drugcoating degradation but prevent endothelial coverage after stenting

降级(电信) 材料科学 生物医学工程 医学 计算机科学 电信
作者
Jun Yin,Chenyang Zhao,Jinbo Huang,Chang Chen,Ting Lei,Jiawei He,Dongxu Qiu
出处
期刊:Acta Biomaterialia [Elsevier BV]
标识
DOI:10.1016/j.actbio.2024.01.034
摘要

The endothelialization of drug-eluting stents is delayed after implantation in patients with diabetes. Although numerous factors were implicated in hyperglycemia-induced endothelial dysfunction, the effects of stent drug coating degradation on endothelial dysfunction remains unclear. We hypothesized that diabetic conditions promote drugcoating degradation and enhance antiproliferative agent release, but that the rapid release of these antiproliferative agents inhibits endothelial cell proliferation leading to poor reendothelialization post-stenting. To verify this hypothesis, a dynamic hyperglycemic circulation system was introduced to measure the profile of drugcoating degradation in vitro. Flow cytometry and RNA sequencing were performed to evaluate endothelial cell proliferation. Moreover, a Type 1 diabetic rabbit model was generated and a rescue experiment conducted to evaluate the effects of rapid drugcoating elution on endothelial coverage in vivo. The main findings were as follows: 1) diabetic conditions promoted drugcoating degradation and increased antiproliferative agent release; 2) this increase in antiproliferative agent release inhibited endothelial cell proliferation and delayed endothelial coverage; and 3) strict glycemic control attenuated drugcoating degradation and promoted endothelial coverage post-stenting. This is the first study to illustrate rapid drugcoating degradation and its potential effects on endothelial recovery under diabetic conditions, highlighting the importance of strict glycemic management in patients with diabetes after drug-eluting stent implantation. Diabetic conditions promote drug coating degradation and increase the release of antiproliferative agents. Rapid drug coating degradation under diabetic conditions inhibits endothelial cell proliferation and delays endothelialization. Strict glycemic control attenuates drug coating degradation and promotes endothelialization.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
一般人发布了新的文献求助10
2秒前
所所应助司空豁采纳,获得10
2秒前
ZHH完成签到,获得积分10
2秒前
4秒前
5秒前
5秒前
6秒前
阿黑路西完成签到,获得积分10
6秒前
888发布了新的文献求助10
6秒前
动听的笑南完成签到,获得积分10
6秒前
萨博发布了新的文献求助10
7秒前
家伟发布了新的文献求助10
8秒前
木木三完成签到 ,获得积分0
9秒前
9秒前
秀丽朝雪发布了新的文献求助10
9秒前
kkk发布了新的文献求助10
10秒前
郁白梦完成签到,获得积分20
10秒前
坚强幼晴完成签到,获得积分10
12秒前
12秒前
13秒前
小马甲应助幽默果汁采纳,获得10
14秒前
乐观德地发布了新的文献求助10
14秒前
量子星尘发布了新的文献求助10
15秒前
16秒前
kkk完成签到,获得积分10
16秒前
摆烂fish完成签到,获得积分10
17秒前
可爱的函函应助lumcy采纳,获得10
18秒前
www发布了新的文献求助10
18秒前
zyj完成签到,获得积分10
18秒前
tong77发布了新的文献求助10
18秒前
乐观小之应助科研通管家采纳,获得10
19秒前
乐观小之应助科研通管家采纳,获得10
19秒前
8R60d8应助科研通管家采纳,获得10
19秒前
Orange应助科研通管家采纳,获得10
19秒前
充电宝应助科研通管家采纳,获得10
19秒前
英俊的铭应助科研通管家采纳,获得10
19秒前
跳跃幻丝应助科研通管家采纳,获得10
19秒前
酷波er应助科研通管家采纳,获得10
20秒前
CipherSage应助科研通管家采纳,获得10
20秒前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
T/CIET 1202-2025 可吸收再生氧化纤维素止血材料 500
Interpretation of Mass Spectra, Fourth Edition 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3956458
求助须知:如何正确求助?哪些是违规求助? 3502568
关于积分的说明 11108738
捐赠科研通 3233292
什么是DOI,文献DOI怎么找? 1787239
邀请新用户注册赠送积分活动 870565
科研通“疑难数据库(出版商)”最低求助积分说明 802122