癌症免疫疗法
免疫系统
癌症
癌细胞
免疫疗法
化学
癌症研究
免疫检查点
抗原
免疫学
医学
内科学
作者
Xianglian He,Guidong Gong,Mei Chen,Haojie Zhang,Yajing Zhang,Joseph J. Richardson,Wood Yee Chan,Yunxiang He,Junling Guo
标识
DOI:10.1002/ange.202314501
摘要
Abstract Due to the presence of natural neoantigens, autologous tumor cells hold great promise as personalized therapeutic vaccines. Yet autologous tumor cell vaccines require multi‐step production that frequently leads to the loss of immunoreactive antigens, causing insufficient immune activation and significantly hampering their clinical applications. Herein, we introduce a novel whole‐cell cancer vaccine by cloaking cancer cells with lipopolysaccharide‐decorated manganese(II)‐phenolic networks (MnTA nanocloaks) to evoke tumor‐specific immune response for highly efficacious synergistic cancer immunotherapy. The natural polyphenols coordinate with Mn 2+ and immediately adhere to the surface of individual cancer cells, thereby forming a nanocloak and encapsulating tumor neoantigens. Subsequent decoration with lipopolysaccharide induces internalization by dendritic cells, where Mn 2+ ions are released in the cytosol, further facilitating the activation of the stimulator of the interferon genes (STING) pathway. Highly effective tumor suppression was observed by combining the nanocloaked cancer cell treatment with anti‐programmed cell death ligand 1 (anti‐PD‐L1) antibodies‐mediated immune checkpoint blockade therapy. Our work demonstrates a universal yet simple strategy to engineer a cell‐based nanobiohybrid system for enhanced cancer immunotherapy.
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