Seeking for Regulatory Mechanisms of Phospholamban Expression

HomeCirculation ResearchVol. 134, No. 3Seeking for Regulatory Mechanisms of Phospholamban Expression No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextSeeking for Regulatory Mechanisms of Phospholamban Expression Cecilia Mundiña-Weilenmann Cecilia Mundiña-WeilenmannCecilia Mundiña-Weilenmann Correspondence to: Cecilia Mundiña-Weilenmann, PhD, Centro de Investigaciones Cardiovasculares Facultad de Ciencias Médicas, UNLP 60 y 120, 1900 La Plata, Argentina. Email E-mail Address: [email protected] Centro de Investigaciones Cardiovasculares, CCT-CONICET La Plata, Cátedra de Fisiología y Física Biológica, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina. Originally published1 Feb 2024https://doi.org/10.1161/CIRCRESAHA.124.324109Circulation Research. 2024;134:266–268This article is a commentary on the followingZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through PhospholambanFootnotesFor Sources of Funding and Disclosures, see page 267.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Cecilia Mundiña-Weilenmann, PhD, Centro de Investigaciones Cardiovasculares Facultad de Ciencias Médicas, UNLP 60 y 120, 1900 La Plata, Argentina. Email cmundweil@med.unlp.edu.arREFERENCES1. Eisner DA, Caldwell JL, Kistamás K, Trafford AW. Calcium and excitation-contraction coupling in the heart.Circ Res. 2017; 121:181–195. doi: 10.1161/CIRCRESAHA.117.310230LinkGoogle Scholar2. Haghighi K, Bidwell P, Kranias EG. 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Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-{alpha}1 and involves targeted covalent histone modifications.Endocrinology. 2010; 151:2946–2956. doi: 10.1210/en.2009-1241CrossrefMedlineGoogle Scholar13. Ren AJ, Wei C, Liu YJ, Liu M, Wang P, Fan J, Wang K, Zhang S, Qin Z, Ren QX, et al. ZBTB20 regulates SERCA2a activity and myocardial contractility through phospholamban.Circ Res. 2024; 134:252–265. doi: 10.1161/CIRCRESAHA.123.323798LinkGoogle Scholar14. Ren AJ, Chen C, Zhang S, Liu M, Wei C, Wang K, Ma X, Song Y, Wang R, Zhang H, et al. Zbtb20 deficiency causes cardiac contractile dysfunction in mice.FASEB J. 2020; 34:13862–13876. doi: 10.1096/fj.202000160RRCrossrefMedlineGoogle Scholar15. Luo W, Grupp IL, Harrer J, Ponniah S, Grupp G, Duffy JJ, Doetschman T, Kranias EG. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.Circ Res. 1994; 75:401–409. doi: 10.1161/01.res.75.3.401LinkGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. 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