催化作用
甲酰胺
化学
小学(天文学)
锰
甲醇
氢
组合化学
选择性
基础(拓扑)
基质(水族馆)
有机化学
物理
地质学
数学分析
海洋学
数学
天文
作者
Jiale Ji,Yinghao Huo,Zhaowen Dai,Zhe‐Ning Chen,Tao Tu
标识
DOI:10.1002/anie.202318763
摘要
Abstract The synthesis of mono‐ N ‐methylated aliphatic primary amines has traditionally been challenging, requiring noble metal catalysts and high‐pressure H 2 for achieving satisfactory yields and selectivity. Herein, we developed an approach for the selective coupling of methanol and aliphatic primary amines, without high‐pressure hydrogen, using a manganese‐based catalyst. Remarkably, up to 98 % yields with broad substrate scope were achieved at low catalyst loadings. Notably, due to the weak base‐catalyzed alcoholysis of formamide intermediates, our novel protocol not only obviates the addition of high‐pressure H 2 but also prevents side secondary N ‐methylation, supported by control experiments and density functional theory calculations.
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