A novel quantitative urine LAM antigen strip for point-of-care tuberculosis diagnosis in non-HIV adults

We read with interest the systematic review by Ashar et al. in which the implementation of lateral flow lipoarabinomannan (LAM)-based tuberculosis (TB) testing among HIV-positive inpatients is recommended.1 Detecting urinary LAM may represent a promising approach to address the gap in TB diagnosis,2 which is rapid, economical, and available at point-of-care (POC) and utilizes non-sputum samples to cater to populations who have difficulty producing diagnostic sputum samples.1,3 However, limited sensitivity has impeded its widespread adoption.