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Machine learning based on magnetic resonance imaging and clinical parameters helps predict mesenchymal-epithelial transition factor expression in oral tongue squamous cell carcinoma: a pilot study

舌头 磁共振成像 上皮-间质转换 间充质干细胞 基底细胞 医学 病理 癌症研究 肿瘤科 放射科 内科学 癌症 转移
作者
Gongxin Yang,Zebin Xiao,Jiliang Ren,Ronghui Xia,Yingwei Wu,Ying Yuan,Xiaofeng Tao
出处
期刊:Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology [Elsevier BV]
卷期号:137 (4): 421-430 被引量:4
标识
DOI:10.1016/j.oooo.2023.12.789
摘要

Objectives : This study aimed to develop machine learning models to predict phosphorylated mesenchymal-epithelial transition factor (p-MET) expression in oral tongue squamous cell carcinoma (OTSCC) using magnetic resonance imaging (MRI)-derived texture features and clinical features. Methods : Thirty-four patients with OTSCC were retrospectively collected. Texture features were derived from preoperative MR images, including T2WI, apparent diffusion coefficient mapping, and contrast-enhanced (ce)-T1WI. Dimension reduction was performed consecutively with reproducibility analysis and an information gain algorithm. Five machine learning methods - AdaBoost, logistic regression (LR), naïve Bayes (NB), random forest (RF), and support vector machine (SVM) - were adopted to create models predicting p-MET expression. Their performance was assessed with fivefold cross-validation. Results : In total, 22 and 12 cases showed low and high p-MET expression, respectively. After dimension reduction, 3 texture features (ADC-Minimum, ce-T1WI-Imc2, and ce-T1WI-DependenceVariance) and 2 clinical features (depth of invasion (DOI) and T-stage) were selected with good reproducibility and best correlation with p-MET expression levels. The RF model yielded the best overall performance, correctly classifying p-MET expression status in 87.5% of OTSCCs with an area under the receiver operating characteristic curve of 0.875. Conclusion : Differences in p-MET expression in OTSCCs can be noninvasively reflected in MRI-based texture features and clinical parameters. Machine learning can potentially predict biomarker expression levels, such as MET, in patients with OTSCC. Statement of Clinical Relevance : A predictive model using machine learning based on MRI texture and clinical features demonstrates promise in predicting expression of p-MET in OTSCC. This could improve treatment decision-making, targeted therapy related to MET, and prognosis assessment.
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