机制(生物学)
子痫前期
发病机制
生物信息学
医学
病因学
病理生理学
怀孕
生物
免疫学
病理
遗传学
哲学
认识论
作者
Wenjing Zhou,Xiuying Li,Xin Li,Yaojia Liu,Wenling Song,Qiwei Yang
出处
期刊:Life Sciences
[Elsevier]
日期:2024-02-01
卷期号:338: 122407-122407
标识
DOI:10.1016/j.lfs.2023.122407
摘要
Preeclampsia (PE) is a common pregnancy-induced hypertension disorder that poses a significant threat to the health of pregnant women and fetuses, and has become a leading cause of maternal, fetal, and neonatal mortality. Currently, the therapy strategy for PE is mainly prevention management and symptomatic treatment, and only delivery can completely terminate PE. Therefore, a deeper understanding of the pathogenesis of PE is needed to make treatment and prevention more effective and targeted. With the deepening of molecular etiology research, circular RNAs (circRNAs) have been found to be widely involved in various processes of PE pathogenesis. As a kind of RNA with a special "head to tail" loop structure, the characteristics of circRNAs enable them to play diverse roles in the pathophysiology of PE, and can also serve as ideal biomarkers for early prediction and monitoring progression of PE. In this review, we summarized the latest research on PE-related circRNAs, trying to elucidate the unique or shared roles of circRNAs in various pathophysiological mechanisms of PE, aiming to provide a whole picture of current research on PE-related circRNAs, and extend a new perspective for the precise screening and targeted therapy of PE.
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