Heterogeneity of obstructive sleep apnea phenotypes after ischemic stroke: Outcome variation by cluster analysis

冲程(发动机) 医学 内科学 阻塞性睡眠呼吸暂停 队列 睡眠呼吸暂停 物理疗法 队列研究 生活质量(医疗保健) 星团(航天器) 心脏病学 计算机科学 机械工程 工程类 护理部 程序设计语言
作者
Sandeep Khot,Lynda D. Lisabeth,Madeline Kwicklis,Ronald D. Chervin,Erin Case,Sonja G. Schütz,Devin L. Brown
出处
期刊:Sleep Medicine [Elsevier]
卷期号:114: 145-150 被引量:1
标识
DOI:10.1016/j.sleep.2023.12.027
摘要

Obstructive sleep apnea (OSA) is common but under-recognized after stroke. The aim of this study was to determine whether post-stroke phenotypic OSA subtypes are associated with stroke outcome in a population-based observational cohort. Ischemic stroke patients (n = 804) diagnosed with OSA (respiratory event index ≥10) soon after ischemic stroke were identified from the Brain Attack Surveillance in Corpus Christi (BASIC) project. Functional, cognitive, and quality of life outcomes were assessed at 90 days post-stroke and long-term stroke recurrence was ascertained. Latent profile analysis was performed based on demographic and clinical features, pre-stroke sleep characteristics, OSA severity, and vascular risk factors. Regression models were used to assess the association between phenotypic clusters and outcomes. Four distinct phenotypic clusters provided the best fit. Cluster 1 was characterized by more severe stroke; cluster 2 by severe OSA and higher prevalence of medical comorbidities; cluster 3 by mild stroke and mild OSA; and cluster 4 by moderate OSA and mild stroke. Compared to cluster 3 and after adjustment for baseline stroke severity, cluster 1 and cluster 2 had worse 90-day functional outcome and cluster 1 also had worse quality of life. No difference in cognitive outcome or stroke recurrence rate was noted by cluster. Post-stroke OSA is a heterogeneous disorder with different clinical phenotypes associated with stroke outcomes, including both daily function and quality of life. The unique presentations of OSA after stroke may have important implications for stroke prognosis and personalized treatment strategies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
HUU发布了新的文献求助10
刚刚
二条发布了新的文献求助10
刚刚
FashionBoy应助范曼冬采纳,获得10
1秒前
1秒前
Ade发布了新的文献求助10
1秒前
Akim应助酷炫觅松采纳,获得10
2秒前
ppp完成签到,获得积分10
3秒前
4秒前
额额完成签到,获得积分10
4秒前
斯文败类应助含蓄戾采纳,获得10
5秒前
lia完成签到,获得积分10
5秒前
小吴同学发布了新的文献求助10
5秒前
5秒前
5秒前
SCI发发发完成签到,获得积分10
6秒前
6秒前
肉丝完成签到,获得积分10
6秒前
8秒前
wujx589发布了新的文献求助10
8秒前
雪糕发布了新的文献求助10
10秒前
张一诺021222完成签到,获得积分10
10秒前
12秒前
13秒前
忧郁的莫茗完成签到,获得积分10
13秒前
ZZZ发布了新的文献求助10
14秒前
称心的访彤完成签到,获得积分10
14秒前
852应助明亮的卿采纳,获得10
15秒前
15秒前
尉迟衣发布了新的文献求助10
15秒前
hearz完成签到,获得积分10
15秒前
小二郎应助Lobectomy采纳,获得10
16秒前
17秒前
完美世界应助科研通管家采纳,获得10
17秒前
思源应助科研通管家采纳,获得10
17秒前
17秒前
FashionBoy应助科研通管家采纳,获得10
17秒前
从容芮应助科研通管家采纳,获得10
17秒前
顾矜应助科研通管家采纳,获得10
17秒前
桐桐应助科研通管家采纳,获得10
17秒前
无花果应助六碗鱼采纳,获得10
17秒前
高分求助中
Evolution 10000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Distribution Dependent Stochastic Differential Equations 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3158072
求助须知:如何正确求助?哪些是违规求助? 2809436
关于积分的说明 7881999
捐赠科研通 2467898
什么是DOI,文献DOI怎么找? 1313783
科研通“疑难数据库(出版商)”最低求助积分说明 630538
版权声明 601943