脑岛
默认模式网络
静息状态功能磁共振成像
重性抑郁障碍
功能磁共振成像
心理学
心率变异性
萧条(经济学)
听力学
大脑活动与冥想
前额叶皮质
神经科学
医学
心脏病学
内科学
心率
认知
脑电图
血压
经济
宏观经济学
作者
Manuel Blickle,Catherina Klüpfel,György A. Homola,Matthias Gamer,Martin J. Herrmann,Stefan Störk,Götz Gelbrich,Peter U. Heuschmann,Jürgen Deckert,Mirko Pham,Andreas Menke
标识
DOI:10.1016/j.jpsychires.2023.11.044
摘要
Major depressive disorder (MDD) is associated with increased cardiac morbidity. Reduced heart rate variability (HRV) as well as lower interoceptive accuracy (IAc) have been observed in MDD as possible sympathomimetic mechanisms related to insula activity. The salience network (SN) anchored by the insula has been posited as a crucial functional network for cardiac sensations and the default mode network (DMN) for MDD. This study aimed to investigate the relation between insula-centered and depression-related brain networks, IAc and HRV in patients with depression as a possible mechanism by which MDD increases cardiac morbidity. 30 depressed inpatients and 30 healthy subjects (derived from the population-based "Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression" cohort study, STAAB) all over 50 years were examined. HRV and IAc were assessed via electrocardiogram and a heartbeat perception task prior to a 3 T resting-state functional magnetic resonance imaging. Seed-to-voxel resting-state functional connectivity (FC) analysis was conducted with six seeds in the insula and two seeds in the DMN. Depressed patients on the one hand showed decreased FC between insula cortex and frontal as well occipital cortical brain regions compared to controls. Depressed patients on the other hand exhibited higher FC between the medial prefrontal cortex and the insula cortex compared to controls. However, depressed patients did not differ in HRV nor in IAc compared to controls. Thus, differences in insula-related brain networks in depression in our study were not mirrored by differences in HRV and IAc. Future research is needed to define the mechanism by which depression increases cardiac morbidity.
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