Diffusion kurtosis imaging reveals abnormal gray matter and white matter development in some brain regions of children with attention‐deficit/hyperactivity disorder

部分各向异性 白质 尾状核 峰度 额叶 磁共振弥散成像 壳核 心理学 颞叶 注意缺陷多动障碍 苍白球 医学 核医学 神经科学 磁共振成像 基底神经节 放射科 精神科 中枢神经系统 癫痫 统计 数学
作者
Shilong Tang,Xianfan Liu,Lisha Nie,Fangfang Qian,Wushuang Chen,Ling He,Mei Yang
出处
期刊:Journal of Neuroscience Research [Wiley]
卷期号:102 (1) 被引量:3
标识
DOI:10.1002/jnr.25284
摘要

Abstract In this study, we explored the application of diffusion kurtosis imaging (DKI) technology in the brains of children with attention‐deficit/hyperactivity disorder (ADHD). Seventy‐two children with ADHD and 79 age‐ and sex‐matched healthy controls were included in the study. All children were examined by means of 3D T1‐weighted image, DKI, and conventional sequence scanning. The volume and DKI parameters of each brain region were obtained by software postprocessing (GE ADW 4.6 workstation) and compared between the two groups of children to determine the imaging characteristics of children with ADHD. The result showed the total brain volume was lower in children with ADHD than in healthy children ( p < .05). The gray and white matter volumes in the frontal lobe, temporal lobe, hippocampus, caudate nucleus, putamen, globus pallidus, and other brain regions were lower in children with ADHD than in healthy children ( p < .05). The axial kurtosis (Ka), mean kurtosis (MK), fractional anisotropy (FA), and radial kurtosis(Kr) values in the frontal lobe, temporal lobe, and caudate nucleus of children with ADHD were lower than those of healthy children, while the mean diffusivity(MD) and fractional anisotropy of kurtosis (FAK) values were higher than those of healthy children ( p < .05). Additionally, the Ka, MK, FA, and Kr values in the frontal lobe, caudate nucleus, and temporal lobe could be used to distinguish children with ADHD (AUC > .05, p < .05). In conclusion, DKI showed abnormal gray matter and white matter development in some brain regions of children with ADHD.
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