Fabrication of facile assembly shrinkable double-responsive nanoparticles: Investigation of anticancer activity in lung cancer cells and apoptosis induction

癌细胞 药物输送 阿霉素 化学 A549电池 细胞凋亡 药品 纳米载体 体外 细胞毒性T细胞 细胞外基质 活性氧 癌症研究 癌症 药理学 生物化学 化疗 生物 有机化学 遗传学
作者
Zhe Chen,Tingjian Li,Kangtai Ying,Liping Xie,Bingqing Ruan
出处
期刊:Process Biochemistry [Elsevier]
卷期号:137: 175-186
标识
DOI:10.1016/j.procbio.2023.12.023
摘要

Nanoparticle-based delivery techniques have low stability, poor tumour penetration, and uncontrolled drug release. To address these issues, the present study designed HAD (the compound of Halloysite (HS), alginate oligosaccharides (AOS), and doxorubicin (DOX)). This shrinkable nanoparticle responds to changes in pH and enzyme activity in the tumour microenvironment. DOX, an anticancer drug in HAD, is durable in serum-comprising water solutions and readily accumulates in tumours in vitro, despite its small size (100 nm). Because of the abundance of lysozymes in the tumour extracellular matrix, HAD can be reduced from 100 nm to 30 nm (in size), allowing the drug to enter the tumour tissue more easily. In addition, once internalised by tumour cells, the DOX is rapidly released, and the acidic and enzymatic cellular microenvironment quickly kills the cancer cells. An excellent reduction in the A549 cells' dose-dependent viability observed the HAD's cytotoxic potential. The enhanced reactive oxygen species (ROS) accumulations and reduction of MMP were perceived in the HAD-treated cells. The improved caspase-3, −9, and −8 expressions were also seen in the HAD-exposed A549 cells. These findings show that HAD has been promised as a beneficial delivery method for cancer treatment since it can assure a regulated drug release specifically targeted to lung tumour cells.
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