光动力疗法
过氧亚硝酸盐
一氧化氮
化学
单线态氧
超氧化物
肿瘤微环境
谷胱甘肽
氧气
癌症研究
肿瘤细胞
生物化学
有机化学
医学
酶
作者
Jianhua Zou,Zheng Li,Yang Zhu,Yucen Tao,Qing You,Fangfang Cao,Qinghe Wu,Min Wu,Junjie Cheng,Jianwei Zhu,Xiaoyuan Chen
标识
DOI:10.1016/j.bioactmat.2023.12.023
摘要
Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy (PDT) due to oxygen consumption. Type I PDT, which can operate independently of oxygen, is a viable option for treating hypoxic tumors. In this study, we have designed and synthesized JSK@PEG-IR820 NPs that are responsive to the tumor microenvironment (TME) to enhance type I PDT through glutathione (GSH) depletion. Our approach aims to expand the sources of therapeutic benefits by promoting the generation of superoxide radicals (O2−.) while minimizing their consumption. The diisopropyl group within PEG-IR820 serves a dual purpose: it functions as a pH sensor for the disassembly of the NPs to release JSK and enhances intermolecular electron transfer to IR820, facilitating efficient O2−. generation. Simultaneously, the release of JSK leads to GSH depletion, resulting in the generation of nitric oxide (NO). This, in turn, contributes to the formation of highly cytotoxic peroxynitrite (ONOO−.), thereby enhancing the therapeutic efficacy of these NPs. NIR-II fluorescence imaging guided therapy has achieved successful tumor eradication with the assistance of laser therapy.
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