Clinical epidemiology and a novel predicting nomogram of central line associated bloodstream infection in burn patients

列线图 医学 流行病学 鲍曼不动杆菌 中心静脉导管 内科学 接收机工作特性 血流感染 中心线 急诊医学 铜绿假单胞菌 重症监护医学 外科 导管 生物 细菌 遗传学
作者
Yangping Wang,Qimeng Li,Qin Shu,Menglong Liu,Ning Li,Wen Sui,Zhiqiang Yuan,Gaoxing Luo,Haisheng Li
出处
期刊:Epidemiology and Infection [Cambridge University Press]
卷期号:151 被引量:2
标识
DOI:10.1017/s0950268823000766
摘要

Burn patients are at high risk of central line-associated bloodstream infection (CLABSI). However, the diagnosis of such infections is complex, resource-intensive, and often delayed. This study aimed to investigate the epidemiology of CLABSI and develop a prediction model for the infection in burn patients. The study analysed the infection profiles, clinical epidemiology, and central venous catheter (CVC) management of patients in a large burn centre in China from January 2018 to December 2021. In total, 222 burn patients with a cumulative 630 CVCs and 5,431 line-days were included. The CLABSI rate was 23.02 CVCs per 1000 line-days. The three most common bacterial species were Acinetobacter baumannii, Staphylococcus aureus, and Pseudomonas aeruginosa; 76.09% of isolates were multidrug resistant. Compared with a non-CLABSI cohort, CLABSI patients were significantly older, with more severe burns, more CVC insertion times, and longer total line-days, as well as higher mortality. Regression analysis found longer line-days, more catheterisation times, and higher burn wounds index to be independent risk factors for CLABSI. A novel nomogram based on three risk factors was constructed with an area under the receiver operating characteristic curve (AUROC) value of 0.84 (95% CI: 0.782-0.898) with a mean absolute error of calibration curve of 0.023. The nomogram showed excellent predictive ability and clinical applicability, and provided a simple, practical, and quantitative strategy to predict CLABSI in burn patients.
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