Inositol 1,4,5‐trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population

单核苷酸多态性 乳腺癌 优势比 SNP公司 生物 遗传学 基因 肿瘤科 内科学 癌症 基因型 医学
作者
Jiaping Chen,Jing Zhou,Yue Jiang,Yuzhuo Wang,Congcong Chen,Tao Jiang,Jiangbo Du
出处
期刊:Journal of Gene Medicine [Wiley]
卷期号:25 (2) 被引量:1
标识
DOI:10.1002/jgm.3463
摘要

Abstract Background Mammalian inositol 1,4,5‐trisphosphate receptor (ITPR) genes encode ubiquitously expressed endoplasmic reticulum Ca 2+ channels that have recently been shown to be closely linked to the pathogenesis of several cancers. However, few studies to date have explored associations between ITPR gene family single nucleotide polymorphisms (SNPs) and breast cancer risk. Methods In the present case–control study, 12 SNPs in the potential functional regions of the ITPR1 , ITPR2 , and ITPR3 genes were genotyped using an Illumina Infinium® Beadchip in 2095 Chinese women (1032 cases and 1063 controls). Results Multivariate logistic regression analyses indicated that a missense SNP in the ITPR3 coding region (rs2229642) was significantly related to breast cancer risk when using an additive model in this study (rs2229642‐adjusted odds ratio = 1.40, 95% confidence interval = 1.12–1.74, p = 2.97 × 10 −3 ). Expression quantitative trait loci analyses indicated that the SNP rs2229642 was associated with reduced ITPR3 expression levels ( p = 3.2 × 10 −7 ) and with marked reductions in the expressions of several proximal genes, including BAK1 , GRM4 , HLA‐DOB , and UQCC2 ( p = 0.013, 0.018, 3.4 × 10 −3 , 3.8 × 10 −5 ), suggesting that it may further regulate other genes associated with oncogenic susceptibility. Kaplan–Meier analyses indicated that the patients with higher ITPR3 expression exhibited significantly poorer outcomes compared to the patients with lower expression of this gene (hazard ratio = 1.11, 95% confidence interval = 1–1.23, p = 0.046). Conclusions The results indicated that genetic variant in the coding region of ITPR3 gene may regulate the expressions of its host and some other cancer‐related genes, as well as act as potential predictive biomarker for susceptibility to breast cancer in the Chinese population.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Neuro_dan发布了新的文献求助80
刚刚
1秒前
12345发布了新的文献求助20
3秒前
3秒前
啾啾发布了新的文献求助10
4秒前
花花完成签到 ,获得积分20
4秒前
5秒前
luchong发布了新的文献求助30
5秒前
林林发布了新的文献求助10
7秒前
7秒前
科研通AI2S应助辛勤白安采纳,获得10
8秒前
G梦坠关注了科研通微信公众号
9秒前
谌倪发布了新的文献求助10
10秒前
桐桐应助小李采纳,获得10
10秒前
活着斯发布了新的文献求助30
10秒前
11秒前
LMR发布了新的文献求助10
11秒前
JamesPei应助小麦采纳,获得10
12秒前
13秒前
13秒前
13秒前
jade完成签到,获得积分10
13秒前
景胜杰发布了新的文献求助10
15秒前
NexusExplorer应助捕风的栗子采纳,获得30
16秒前
YY完成签到 ,获得积分10
17秒前
18秒前
18秒前
淡淡的夜山完成签到,获得积分10
19秒前
20秒前
大黑狗发布了新的文献求助10
20秒前
12345完成签到,获得积分10
21秒前
23秒前
斯文败类应助活着斯采纳,获得20
23秒前
小n发布了新的文献求助10
24秒前
25秒前
脑洞疼应助东莨菪碱采纳,获得10
25秒前
执着的灯泡完成签到,获得积分10
26秒前
么么么发布了新的文献求助10
29秒前
29秒前
30秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3247668
求助须知:如何正确求助?哪些是违规求助? 2890943
关于积分的说明 8265433
捐赠科研通 2559211
什么是DOI,文献DOI怎么找? 1387967
科研通“疑难数据库(出版商)”最低求助积分说明 650670
邀请新用户注册赠送积分活动 627505