神经发生
神经科学
神经保护
神经炎症
认知功能衰退
衰老的大脑
氧化应激
脑老化
医学
生物
认知
炎症
痴呆
内分泌学
内科学
疾病
作者
Sergio Davinelli,Alessandro Medoro,Sawan Alì,Daniela Passarella,Mariano Intrieri,Giovanni Scapagnini
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2023-03-01
卷期号:21 (3): 651-668
被引量:2
标识
DOI:10.2174/1570159x21666221031103909
摘要
Adult neurogenesis deficiency has been proposed to be a common hallmark in different age-related neurodegenerative diseases. The administration of flavonoids is currently reported as a potentially beneficial strategy for preventing brain aging alterations, including adult neurogenesis decline. Flavonoids are a class of plant-derived dietary polyphenols that have drawn attention for their neuroprotective and pro-cognitive effects. Although they undergo extensive metabolism and localize in the brain at low concentrations, flavonoids are now believed to improve cerebral vasculature and interact with signal transduction cascades involved in the regulation of adult neurogenesis. Furthermore, many dietary flavonoids have been shown to reduce oxidative stress and neuroinflammation, improving the neuronal microenvironment where adult neurogenesis occurs. The overall goal of this review is to summarize the evidence supporting the role of flavonoids in modulating adult neurogenesis as well as to highlight how these dietary agents may be promising candidates in restoring healthy brain function during physiological and pathological aging.
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