清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Clinical performance of an antibody-free assay for plasma Aβ42/Aβ40 to detect early alterations of Alzheimer’s disease in individuals with subjective cognitive decline

四分位间距 队列 医学 内科学 记忆诊所 置信区间 痴呆 认知功能衰退 接收机工作特性 胃肠病学 疾病
作者
María Pascual‐Lucas,José Antonio Allué,Leticia Sarasa,Noelia Fandos,Sergio Castillo,J. Terencio,Manuel Sarasa,Juan Pablo Tartari,Ángela Sanabria,Lluís Tárraga,Agustı́n Ruiz,Marta Marquié,Sang Won Seo,Hyemin Jang,Merçé Boada,N. Aguilera,Emilio Alarcón‐Martín,Montserrat Alegret,Silvia Alonso‐Lana,Marcelo L. Berthier,U. Bojayrin,Mar Buendía,Santiago Bullich,Francisco Campos,Amanda Cano,Pilar Cañabate,L. Cañada,Claudia Cuevas,Itziar de Rojas,S. Diego,Ana Espinosa,Ester Esteban‐De Antonio,A. Gailhajenet,Asunción Garcı́a-Sánchez,Philip Garcia,J.C. Juárez Giménez,Marta Gómez‐Chiari,M. Guitart,Iván Hernández Ramírez,Marta Ibarria,A. Lafuente,Núria Lleonart,F. Lomeña,E. Martín,M. Moreno,A.M. Morera,Laura Montrreal,N. Muñoz,Leire Narvaiza,A. Niñerola,A. B. Nogales,L. Núñez,Adelina Orellana,Gemma Ortega,Antonio Páez,Ana Pancho,E. Pelejà,Elsa Pérez,Alba Pérez‐Cordón,Andrés Perissinotti,Sílvia Preckler,Vanesa Pytel,Mario Ricciardi,Octavio Rodríguez‐Gómez,Núria Roé-Vellvé,Maribel Ramis,Maitée Rosende‐Roca,S. Seguer,Óscar Sotolongo‐Grau,Andrew Stephens,Miguel Ángel Tejero,M.D. Martínez del Valle Torres,Sergi Valero,Luis Vargas,Assumpta Vivas
出处
期刊:Alzheimer's Research & Therapy [BioMed Central]
卷期号:15 (1) 被引量:25
标识
DOI:10.1186/s13195-022-01143-z
摘要

Accessible and cost-effective diagnostic tools are urgently needed to accurately quantify blood biomarkers to support early diagnosis of Alzheimer's disease (AD). In this study, we investigated the ability of plasma amyloid-beta (Aβ)42/Aβ40 ratio measured by an antibody-free mass-spectrometric (MS) method, ABtest-MS, to detect early pathological changes of AD.This cohort study included data from the baseline and 2-year follow-up visits from the Fundació ACE Healthy Brain Initiative (FACEHBI) study. Plasma Aβ42/Aβ40 was measured with ABtest-MS and compared to 18F-Florbetaben PET as the reference standard (cutoff for early amyloid deposition of 13.5 centiloids). Cross-validation was performed in an independent DPUK-Korean cohort. Additionally, associations of plasma Aβ42/Aβ40 with episodic memory performance and brain atrophy were assessed.The FACEHBI cohort at baseline included 200 healthy individuals with subjective cognitive decline (SCD), of which 36 (18%) were Aβ-PET positive. Plasma Aβ42/Aβ40 levels were significantly lower in Aβ-PET positive individuals (median [interquartile range, IQR], 0.215 [0.203-0.236]) versus Aβ-PET negative subjects (median [IQR], 0.261 [0.244-0.279]) (P < .001). Plasma Aβ42/Aβ40 was significantly correlated with Aβ-PET levels (rho = -0.390; P < .001) and identified Aβ-PET status with an area under the receiver operating characteristic curve (AUC) of 0.87 (95% confidence interval [CI], 0.80-0.93). A cutoff for the Aβ42/Aβ40 ratio of 0.241 (maximum Youden index) yielded a sensitivity of 86.1% and a specificity of 80.5%. These findings were cross-validated in an independent DPUK-Korean cohort (AUC 0.86 [95% CI 0.77-0.95]). Lower plasma Aβ42/Aβ40 ratio was associated with worse episodic memory performance and increased brain atrophy. Plasma Aβ42/Aβ40 at baseline predicted clinical conversion to mild cognitive impairment and longitudinal changes in amyloid deposition and brain atrophy at 2-year follow-up.This study suggests that plasma Aβ42/Aβ40, as determined by this MS-based assay, has potential value as an accurate and cost-effective tool to identify individuals in the earliest stages of AD, supporting its implementation in clinical trials, preventative strategies and clinical practice.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ZIS发布了新的文献求助10
5秒前
孤独听雨的猫完成签到 ,获得积分10
9秒前
harden9159完成签到,获得积分10
13秒前
ys1008完成签到,获得积分10
16秒前
文献蚂蚁完成签到,获得积分10
16秒前
美满惜寒完成签到,获得积分10
16秒前
真的OK完成签到,获得积分10
16秒前
啪嗒大白球完成签到,获得积分10
16秒前
洋芋饭饭完成签到,获得积分10
16秒前
CGBIO完成签到,获得积分10
16秒前
BMG完成签到,获得积分10
17秒前
朝夕之晖完成签到,获得积分10
17秒前
嫁个养熊猫的完成签到 ,获得积分10
24秒前
老迟到的羊完成签到 ,获得积分10
27秒前
大模型应助科研通管家采纳,获得10
28秒前
氕氘氚完成签到 ,获得积分10
40秒前
医学耗材完成签到 ,获得积分10
44秒前
毕业就集采的苦命人完成签到 ,获得积分10
55秒前
且行丶且努力完成签到,获得积分10
58秒前
ranj完成签到,获得积分10
1分钟前
DJ_Tokyo完成签到,获得积分0
1分钟前
墨言无殇完成签到 ,获得积分10
1分钟前
1分钟前
CF完成签到 ,获得积分10
1分钟前
tmobiusx完成签到,获得积分10
1分钟前
mc完成签到 ,获得积分10
1分钟前
我要读博士完成签到 ,获得积分10
2分钟前
辣小扬完成签到 ,获得积分10
2分钟前
2分钟前
gwbk完成签到,获得积分10
2分钟前
jozz完成签到 ,获得积分10
2分钟前
HCCha完成签到,获得积分10
2分钟前
badgerwithfisher完成签到,获得积分10
2分钟前
段誉完成签到 ,获得积分10
2分钟前
虞无声完成签到,获得积分10
3分钟前
3分钟前
雪妮完成签到 ,获得积分10
3分钟前
fogsea完成签到,获得积分0
3分钟前
apckkk完成签到 ,获得积分10
3分钟前
冰霜雨露完成签到 ,获得积分10
3分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968521
求助须知:如何正确求助?哪些是违规求助? 3513358
关于积分的说明 11167301
捐赠科研通 3248700
什么是DOI,文献DOI怎么找? 1794453
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804664