Clinical performance of an antibody-free assay for plasma Aβ42/Aβ40 to detect early alterations of Alzheimer’s disease in individuals with subjective cognitive decline

四分位间距 队列 医学 内科学 记忆诊所 置信区间 痴呆 认知功能衰退 接收机工作特性 胃肠病学 疾病
作者
María Pascual‐Lucas,José Antonio Allué,Leticia Sarasa,Noelia Fandos,Sergio Castillo,J. Terencio,Manuel Sarasa,Juan Pablo Tartari,Ángela Sanabria,Lluís Tárraga,Agustı́n Ruiz,Marta Marquié,Sang Won Seo,Hyemin Jang,Merçé Boada,N. Aguilera,Emilio Alarcón‐Martín,Montserrat Alegret,Silvia Alonso‐Lana,Marcelo L. Berthier,U. Bojayrin,Mar Buendía,Santiago Bullich,Francisco Campos,Amanda Cano,Pilar Cañabate,L. Cañada,Claudia Cuevas,Itziar de Rojas,S. Diego,Ana Espinosa,Ester Esteban‐De Antonio,A. Gailhajenet,Asunción Garcı́a-Sánchez,Philip Garcia,J.C. Juárez Giménez,Marta Gómez‐Chiari,M. Guitart,Iván Hernández Ramírez,Marta Ibarria,A. Lafuente,Núria Lleonart,F. Lomeña,E. Martín,M. Moreno,A.M. Morera,Laura Montrreal,N. Muñoz,Leire Narvaiza,A. Niñerola,A. B. Nogales,L. Núñez,Adelina Orellana,Gemma Ortega,Antonio Páez,Ana Pancho,E. Pelejà,Elsa Pérez,Alba Pérez‐Cordón,Andrés Perissinotti,Sílvia Preckler,Vanesa Pytel,Mario Ricciardi,Octavio Rodríguez‐Gómez,Núria Roé-Vellvé,Maribel Ramis,Maitée Rosende‐Roca,S. Seguer,Óscar Sotolongo‐Grau,Andrew Stephens,Miguel Ángel Tejero,M.D. Martínez del Valle Torres,Sergi Valero,Luis Vargas,Assumpta Vivas
出处
期刊:Alzheimer's Research & Therapy [BioMed Central]
卷期号:15 (1) 被引量:25
标识
DOI:10.1186/s13195-022-01143-z
摘要

Accessible and cost-effective diagnostic tools are urgently needed to accurately quantify blood biomarkers to support early diagnosis of Alzheimer's disease (AD). In this study, we investigated the ability of plasma amyloid-beta (Aβ)42/Aβ40 ratio measured by an antibody-free mass-spectrometric (MS) method, ABtest-MS, to detect early pathological changes of AD.This cohort study included data from the baseline and 2-year follow-up visits from the Fundació ACE Healthy Brain Initiative (FACEHBI) study. Plasma Aβ42/Aβ40 was measured with ABtest-MS and compared to 18F-Florbetaben PET as the reference standard (cutoff for early amyloid deposition of 13.5 centiloids). Cross-validation was performed in an independent DPUK-Korean cohort. Additionally, associations of plasma Aβ42/Aβ40 with episodic memory performance and brain atrophy were assessed.The FACEHBI cohort at baseline included 200 healthy individuals with subjective cognitive decline (SCD), of which 36 (18%) were Aβ-PET positive. Plasma Aβ42/Aβ40 levels were significantly lower in Aβ-PET positive individuals (median [interquartile range, IQR], 0.215 [0.203-0.236]) versus Aβ-PET negative subjects (median [IQR], 0.261 [0.244-0.279]) (P < .001). Plasma Aβ42/Aβ40 was significantly correlated with Aβ-PET levels (rho = -0.390; P < .001) and identified Aβ-PET status with an area under the receiver operating characteristic curve (AUC) of 0.87 (95% confidence interval [CI], 0.80-0.93). A cutoff for the Aβ42/Aβ40 ratio of 0.241 (maximum Youden index) yielded a sensitivity of 86.1% and a specificity of 80.5%. These findings were cross-validated in an independent DPUK-Korean cohort (AUC 0.86 [95% CI 0.77-0.95]). Lower plasma Aβ42/Aβ40 ratio was associated with worse episodic memory performance and increased brain atrophy. Plasma Aβ42/Aβ40 at baseline predicted clinical conversion to mild cognitive impairment and longitudinal changes in amyloid deposition and brain atrophy at 2-year follow-up.This study suggests that plasma Aβ42/Aβ40, as determined by this MS-based assay, has potential value as an accurate and cost-effective tool to identify individuals in the earliest stages of AD, supporting its implementation in clinical trials, preventative strategies and clinical practice.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
动听千风完成签到,获得积分10
刚刚
Cll完成签到 ,获得积分10
1秒前
3秒前
3秒前
3秒前
李可汗完成签到,获得积分20
4秒前
quququ完成签到,获得积分10
4秒前
独特冰安发布了新的文献求助10
4秒前
4秒前
桓某人发布了新的文献求助10
5秒前
5秒前
6秒前
柚子完成签到,获得积分10
6秒前
6秒前
CodeCraft应助DAKE采纳,获得10
6秒前
李憨憨发布了新的文献求助10
6秒前
yuzhang312完成签到,获得积分10
6秒前
大模型应助清风采纳,获得10
7秒前
7秒前
顺利夏之完成签到 ,获得积分10
8秒前
quququ发布了新的文献求助10
8秒前
hzh完成签到,获得积分20
8秒前
宗铁强发布了新的文献求助30
9秒前
eric发布了新的文献求助30
9秒前
10秒前
orixero应助大方弘文采纳,获得10
10秒前
小五关注了科研通微信公众号
10秒前
wanci应助李可汗采纳,获得10
10秒前
搜集达人应助Sene采纳,获得20
11秒前
11秒前
优雅狗发布了新的文献求助200
12秒前
陆千万发布了新的文献求助10
12秒前
yuzhang312发布了新的文献求助10
12秒前
补药学习完成签到,获得积分10
12秒前
shinn发布了新的文献求助10
14秒前
可爱的函函应助欧子采纳,获得10
15秒前
冷艳薯片完成签到,获得积分10
15秒前
bin完成签到,获得积分10
16秒前
漂亮豆芽完成签到,获得积分10
16秒前
16秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975250
求助须知:如何正确求助?哪些是违规求助? 3519625
关于积分的说明 11199055
捐赠科研通 3255962
什么是DOI,文献DOI怎么找? 1798001
邀请新用户注册赠送积分活动 877358
科研通“疑难数据库(出版商)”最低求助积分说明 806298