Normal-Weight Central Obesity and Risk for Mortality

Letters20 June 2017Normal-Weight Central Obesity and Risk for MortalityMark Hamer, PhD, Gary O'Donovan, PhD, David Stensel, PhD, and Emmanuel Stamatakis, PhDMark Hamer, PhDFrom Loughborough University, Loughborough, United Kingdom, and University of Sydney, Sydney, Australia., Gary O'Donovan, PhDFrom Loughborough University, Loughborough, United Kingdom, and University of Sydney, Sydney, Australia., David Stensel, PhDFrom Loughborough University, Loughborough, United Kingdom, and University of Sydney, Sydney, Australia., and Emmanuel Stamatakis, PhDFrom Loughborough University, Loughborough, United Kingdom, and University of Sydney, Sydney, Australia.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: The association between obesity, defined in terms of body mass index (BMI), and mortality in the general population has been controversial ( 1). Various studies have examined whether central obesity has greater predictive utility than BMI. In a 2015 study of 15 184 adults, paradoxical results suggested that centrally obese participants defined as normal weight on the basis of BMI had the worst long-term survival even when compared with their overweight and obese counterparts ( 2).Objective: To replicate these analyses in a larger sample of adults in the general population.Methods: Participants were recruited from 10 survey years of ...References1. Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309:71-82. [PMID: 23280227] doi:10.1001/jama.2012.113905 CrossrefMedlineGoogle Scholar2. Sahakyan KR, Somers VK, Rodriguez-Escudero JP, Hodge DO, Carter RE, Sochor O, et al. Normal-weight central obesity: implications for total and cardiovascular mortality. Ann Intern Med. 2015;163:827-35. [PMID: 26551006]. doi:10.7326/M14-2525 LinkGoogle Scholar3. Mindell J, Biddulph JP, Hirani V, Stamatakis E, Craig R, Nunn S, et al. Cohort profile: the health survey for England. Int J Epidemiol. 2012;41:1585-93. [PMID: 22253315] doi:10.1093/ije/dyr199 CrossrefMedlineGoogle Scholar4. Stokes A, Preston SH. Revealing the burden of obesity using weight histories. Proc Natl Acad Sci U S A. 2016;113:572-7. [PMID: 26729881] doi:10.1073/pnas.1515472113 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Loughborough University, Loughborough, United Kingdom, and University of Sydney, Sydney, Australia.Financial Support: Drs. Hamer and Stensel were supported by the National Institute for Health Research Leicester Biomedical Research Centre, which is a partnership among University Hospitals of Leicester NHS Trust, Loughborough University, and the University of Leicester. Dr. Stamatakis is funded by the National Health and Medical Research Council through a senior research fellowship.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0022.This article was published at Annals.org on 25 April 2017.This article was published at Annals.org on 25 April 2017. 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Less than Half your Height. Five Steps from Science to Screening: A Mini ReviewThe association between leisure-time physical activity, low HDL-cholesterol and mortality in a pooled analysis of nine population-based cohorts 20 June 2017Volume 166, Issue 12Page: 917-918KeywordsBody mass indexCardiovascular diseasesFatsHazard ratioHealth surveysHipMortalityObesityOverweightRibs ePublished: 25 April 2017 Issue Published: 20 June 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...