Safe and Effective Delivery of Amphotericin B: A Survey of Patents

Background: Amphotericin B, designated as the gold standard among antifungal drugs is the only fungicidal effective against systemic fungal infections. But this drug has various pitfalls associated with it, to bypass which various techniques have been employed and resulted in a variety of lipid based commercially available formulations, which demolished only few of the shortcomings associated with this drug. Further, improvement in the delivery systems of Amphotericin B is advancing at increasingly frenetic pace, to surmount its research and to exploit its therapeutic potency with least toxicities. Keywords: Amphotericin B, antifungal activity, lipid-complexes, nanotechnology, NDDS, purification processes.