Use of Antibiotic Core Structures to Generate New and Useful Macrolide Antibiotics

The 'golden age' for antibiotic discovery, from 1940 until the early 1970s, ushered in a new era in humanand animal-health and the associated dramatic increase in human life expectancies.Indeed the possibility of eradicating infectious disease seemed feasible.However it soon became apparent that microorganisms wouldn't be defeated so easily.Their weapon: antibiotic resistance.Today microbial antibiotic resistance is rapidly exhausting our supply of effective compounds and making the possibility of a global public health disaster seems likely.The urgency of this situation has spawned a plethora of new multi-disciplinary research initiatives looking for novel antibiotics and other antimicrobial agents.In this timely book respected international experts summarize the most important research to provide a timely overview of the field.