Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

P70-S6激酶1 mTORC1型 PI3K/AKT/mTOR通路 生物 细胞生物学 核糖体蛋白s6 TOR信号 信号 mTORC2型 激酶 信号转导 雷帕霉素的作用靶点
作者
Brian Magnuson,Bilgen Ekim,Diane C. Fingar
出处
期刊:Biochemical Journal [Portland Press]
卷期号:441 (1): 1-21 被引量:937
标识
DOI:10.1042/bj20110892
摘要

The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely defined roles in cellular and organismal physiology. TORC1 functions as an environmental sensor by integrating signals derived from diverse environmental cues to promote anabolic and inhibit catabolic cellular functions. mTORC1 (mammalian TORC1) phosphorylates and activates S6K1 and S6K2, whose first identified substrate was rpS6 (ribosomal protein S6), a component of the 40S ribosome. Studies over the past decade have uncovered a number of additional S6K1 substrates, revealing multiple levels at which the mTORC1–S6K1 axis regulates cell physiology. The results thus far indicate that the mTORC1–S6K1 axis controls fundamental cellular processes, including transcription, translation, protein and lipid synthesis, cell growth/size and cell metabolism. In the present review we summarize the regulation of S6Ks, their cellular substrates and functions, and their integration within rapidly expanding mTOR (mammalian TOR) signalling networks. Although our understanding of the role of mTORC1–S6K1 signalling in physiology remains in its infancy, evidence indicates that this signalling axis controls, at least in part, glucose homoeostasis, insulin sensitivity, adipocyte metabolism, body mass and energy balance, tissue and organ size, learning, memory and aging. As dysregulation of this signalling axis contributes to diverse disease states, improved understanding of S6K regulation and function within mTOR signalling networks may enable the development of novel therapeutics.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ali发布了新的文献求助30
刚刚
1秒前
感性的穆完成签到,获得积分20
2秒前
2秒前
李泽雄发布了新的文献求助10
3秒前
呵呵哒给呵呵哒的求助进行了留言
4秒前
5秒前
JggHoo发布了新的文献求助10
9秒前
风轻青柠完成签到,获得积分10
9秒前
10秒前
12秒前
12秒前
量子星尘发布了新的文献求助10
12秒前
13秒前
R2L23发布了新的文献求助10
15秒前
15秒前
诚心的扬发布了新的文献求助10
16秒前
17秒前
liupc2019完成签到,获得积分10
18秒前
顾矜应助momo采纳,获得10
19秒前
周em12_发布了新的文献求助10
19秒前
20秒前
21秒前
21秒前
FashionBoy应助ZZZ采纳,获得10
22秒前
24秒前
清爽傲云发布了新的文献求助10
26秒前
26秒前
28秒前
30秒前
嗨嗨害发布了新的文献求助10
30秒前
Eileen发布了新的文献求助10
31秒前
呵呵哒发布了新的文献求助10
34秒前
清爽傲云完成签到,获得积分10
36秒前
36秒前
37秒前
momo发布了新的文献求助10
41秒前
诚心的扬关注了科研通微信公众号
42秒前
44秒前
嗨嗨害完成签到,获得积分10
45秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989297
求助须知:如何正确求助?哪些是违规求助? 3531418
关于积分的说明 11253893
捐赠科研通 3270097
什么是DOI,文献DOI怎么找? 1804884
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809158