生物
细胞生物学
核运输
内体
病毒复制
病毒进入
甲型流感病毒
病毒包膜
病毒
核糖核酸
核出口信号
HDAC6型
病毒学
RNA病毒
组蛋白脱乙酰基酶
细胞核
细胞质
组蛋白
生物化学
DNA
细胞内
基因
标识
DOI:10.1016/bs.aivir.2020.01.001
摘要
Influenza A virus (IAV) is an enveloped virus of the Orthomyxoviridae with a negative-sense single-stranded RNA genome.During virus cell entry, viral and cellular cues are delivered in a stepwise manner within two distinct cellular compartments -the endosomes and the cytosol.Endosome maturation primes the viral core for uncoating by cytosolic host proteins and hostmediated virus disaggregation is essential for genome import and replication in the nucleus.Recent evidence shows that two well-known cellular proteins -histone deacetylase 6 (HDAC6) and karyopherin-ββ2 (kKapββ2) -uncoat influenza virus.HDAC6 is one of eleven HDACs and an X-linked, cytosolic lysine deacetylase.Under normal cellular conditions HDAC6 is the tubulin deacetylase.Under proteasomal stress HDAC6 binds unanchored ubiquitin, dynein and myosin II
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