Influenza A virus uncoating

Influenza A virus (IAV) is an enveloped virus of the Orthomyxoviridae with a negative-sense single-stranded RNA genome.During virus cell entry, viral and cellular cues are delivered in a stepwise manner within two distinct cellular compartments -the endosomes and the cytosol.Endosome maturation primes the viral core for uncoating by cytosolic host proteins and hostmediated virus disaggregation is essential for genome import and replication in the nucleus.Recent evidence shows that two well-known cellular proteins -histone deacetylase 6 (HDAC6) and karyopherin-ββ2 (kKapββ2) -uncoat influenza virus.HDAC6 is one of eleven HDACs and an X-linked, cytosolic lysine deacetylase.Under normal cellular conditions HDAC6 is the tubulin deacetylase.Under proteasomal stress HDAC6 binds unanchored ubiquitin, dynein and myosin II