乳腺癌
厌氧糖酵解
瓦博格效应
糖酵解
小RNA
疾病
生物
癌症
生物信息学
癌症研究
医学
基因
内科学
新陈代谢
遗传学
内分泌学
作者
Min Xia,Shujun Feng,Zuyao Chen,Gebo Wen,Xuyu Zu,Jing Zhong
出处
期刊:Life Sciences
[Elsevier]
日期:2020-03-21
卷期号:250: 117579-117579
被引量:26
标识
DOI:10.1016/j.lfs.2020.117579
摘要
Although extensive research progress has been made in breast cancer in recent years, yet the morbidity and mortality rates of breast cancer are rising, making it the major disease that endangers women's health. Energy metabolism reprogramming is featured by a state termed "aerobic glycolysis" or the Warburg effect that glycolysis is preferred even under aerobic conditions in neoplastic diseases. Widely acknowledged as an emerging hallmark in cancers, this metabolic switch shows a sophisticated role in the pathogenesis of breast cancer. The regulating effect of non-coding RNAs (ncRNAs) composed of microRNAs, long non-coding RNAs and circular RNAs is closely related to the glycolysis in breast cancer. Therefore, understand the mechanisms of ncRNAs of aerobic glycolysis in breast cancer may provide new strategy for the disease.
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