生物
聚糖
疾病
自身免疫性疾病
自身免疫
免疫系统
免疫学
病菌
糖蛋白
抗体
医学
遗传学
病理
作者
Julie Y Zhou,Brian A. Cobb
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2021-04-26
卷期号:39 (1): 511-536
被引量:15
标识
DOI:10.1146/annurev-immunol-101819-074237
摘要
The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions, immunological recognition and activation, and differentiation between self and nonself through a complex array of pathways and mechanisms. These fundamental immunologic roles are further cast into sharp relief in inflammatory, autoimmune, and cancer disease states in which immune regulation goes awry. Here, we review the broad impact of glycans on the immune system and discuss the changes and clinical opportunities associated with the onset of immunologic disease.
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