微气泡
血脑屏障
超声波
聚焦超声
医学
药物输送到大脑
药物输送
中枢神经系统
纳米技术
放射科
材料科学
内科学
作者
Ambre Dauba,Anthony Delalande,Hermes A. S. Kamimura,Allegra Conti,Benoît Larrat,Nicolas Tsapis,Anthony Novell
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2020-11-21
卷期号:12 (11): 1125-1125
被引量:54
标识
DOI:10.3390/pharmaceutics12111125
摘要
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery. Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to disrupt the blood-brain barrier. Many commercially available ultrasound contrast agents and agents specifically designed for therapeutic purposes have been investigated in ultrasound-mediated blood-brain barrier opening studies. The new generation of sono-sensitive agents, such as liquid-core droplets, can also potentially disrupt the blood-brain barrier after their ultrasound-induced vaporization. In this review, we describe the different compositions of agents used for ultrasound-mediated blood-brain barrier opening in recent studies, and we discuss the challenges of the past five years related to the optimal formulation of agents.
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