放射治疗
图层(电子)
医学
材料科学
纳米技术
内科学
作者
Kaiyuan Ni,Guangxu Lan,Christina Chan,Xiaopin Duan,Nining Guo,Samuel S. Veroneau,Ralph R. Weichselbaum,Wenbin Lin
出处
期刊:Matter
[Elsevier BV]
日期:2019-08-28
卷期号:1 (5): 1331-1353
被引量:90
标识
DOI:10.1016/j.matt.2019.06.007
摘要
Summary Checkpoint blockade immunotherapy (CBI) is effective in promoting a systemic immune response against some metastatic tumors. The reliance on the pre-existing immune environment of the tumor, however, limits the efficacy of CBI on a broad spectrum of cancers. Herein, we report the design of a novel nanoscale metal-organic layer (nMOL), Hf-MOL, for effective treatment of local tumors by enabling radiotherapy-radiodynamic therapy (RT-RDT) with low-dose X-rays and, when in combination with an immune checkpoint inhibitor, regression of metastatic tumors by reactivating antitumor immunity and inhibiting myeloid-derived suppressor cells. Owing to the reduced dimensionality, nMOLs allow facile diffusion of reactive oxygen species and exhibit superior RT-RDT effects. The synergy of Hf-MOL-enabled RT-RDT immune activation and anti-programmed death ligand 1 CBI led to robust abscopal effects on a series of bilateral models of colon, head and neck, and breast cancers, as well as significant antimetastatic effects on an orthotopic model of breast cancer.
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