生物变种
多位点VNTR分析
布鲁氏菌
生物
布鲁氏菌病
多位点序列分型
基因分型
拉伤
系统发育树
布鲁氏菌科
打字
全基因组测序
流产布鲁氏菌
谱系(遗传)
遗传学
克莱德
微生物学
基因组
病毒学
基因型
基因
布鲁氏菌
解剖
作者
Mingjun Sun,Mengda Liu,Xiyue Zhang,Ge Zhang,Liangquan Zhu,Jiabo Ding,Zhicheng Zhang,Shixiong Sun,Shufang Sun,Weixing Shao,Peipei Zhang,Jian-dong Zhang,Xiangxiang Sun,Xuezheng Fan,Rong Wei
标识
DOI:10.1016/j.vetmic.2020.108751
摘要
Brucellosis is one of the major zoonotic diseases in the world. In China, understanding on its causative agent Brucella is still limited. Recently, we isolated a Brucella strain XZ19-1 from yak in Lhasa, Tibet. Phenotypical characterization proved that it belongs to B. abortus biovar 4, a biotype that has never been reported in China. MLVA-16 genotyping revealed a novel profile (4-5-3-12-2-2-3-3-8-32-8-5-4-3-3-3) in this strain, while MLST sequence typing demonstrated that it belongs to ST 71. Furthermore, the whole genome of XZ19-1 strain was sequenced. Subsequent phylogenetic analysis demonstrated that XZ19-1was genetically more closely related to B. abortus strains originated from European countries rather than to those collected from China previously. Isolation and identification of XZ19-1 strain may thus indicate a unique Brucella lineage existing in Qing-Tibet plateau. These findings will help to improve the diagnosis and epidemiological studies of brucellosis in animals and human in this part of China.
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