D100 CDX-0159, AN ANTI-KIT MONOCLONAL ANTIBODY, AS A MODULATOR OF MAST CELL-RELATED DISEASES

CDX-0159 is a humanized anti-KIT IgG1 monoclonal antibody being evaluated as a modulator of mast cell (MC)-related diseases including chronic idiopathic urticaria. The receptor KIT regulates MC growth, survival, chemotaxis and degranulation, suggesting KIT inhibition as a unique approach to modulate MC activity. CDX-0159 is a re-engineered variant of CDX-0158, a potent KIT inhibitor that decreased MC numbers in several preclinical models and decreased plasma tryptase levels in cancer patients, indicating a reduction in MC numbers/activity.