The relationship between post-surgery infection and breast cancer recurrence

医学 乳腺癌 癌症复发 肿瘤科 内科学 癌症手术 保乳手术 外科 普通外科 癌症 乳房切除术
作者
Ruth Í. O’Connor,Patrick A. Kiely,Colum Dunne
出处
期刊:Journal of Hospital Infection [Elsevier BV]
卷期号:106 (3): 522-535 被引量:27
标识
DOI:10.1016/j.jhin.2020.08.004
摘要

Breast cancer is the second most prevalent form of cancer in women worldwide, with surgery remaining the standard treatment. The adverse impact of the surgery remains controversial. It has been suggested that systemic factors during the postoperative period may increase the risk of recurrence, specifically surgical site infection (SSI). The aim of this review was to critically appraise current published literature regarding the influence of SSIs, after primary breast cancer surgery, on breast cancer recurrence, and to delve into potential links between these. This systematic review adopted two approaches: to identify the incidence rates and risk factors related to SSI after primary breast cancer surgery; and, secondly, to examine breast cancer recurrence following SSI occurrence. Ninety-nine studies with 484,605 patients were eligible in the SSI-focused searches, and 53 studies with 17,569 patients for recurrence-focused. There was a 13.07% mean incidence of SSI. Six-hundred and thirty-eight Gram-positive and 442 Gram-negative isolates were identified, with methicillin-susceptible Staphylococcus aureus and Escherichia coli most commonly identified. There were 2077 cases of recurrence (11.8%), with 563 cases of local recurrence, 1186 cases of distant and 25 cases which recurred both locally and distantly. Five studies investigated the association between SSI and breast cancer recurrence with three concluding that an association did exist. In conclusion, there is association between SSI and adverse cancer outcomes, but the cellular link between them remains elusive. Confounding factors of retrospective study design, surgery type and SSI definition make results challenging to compare and interpret. A standardized prospective study with appropriate statistical power is justified. Breast cancer is the second most prevalent form of cancer in women worldwide, with surgery remaining the standard treatment. The adverse impact of the surgery remains controversial. It has been suggested that systemic factors during the postoperative period may increase the risk of recurrence, specifically surgical site infection (SSI). The aim of this review was to critically appraise current published literature regarding the influence of SSIs, after primary breast cancer surgery, on breast cancer recurrence, and to delve into potential links between these. This systematic review adopted two approaches: to identify the incidence rates and risk factors related to SSI after primary breast cancer surgery; and, secondly, to examine breast cancer recurrence following SSI occurrence. Ninety-nine studies with 484,605 patients were eligible in the SSI-focused searches, and 53 studies with 17,569 patients for recurrence-focused. There was a 13.07% mean incidence of SSI. Six-hundred and thirty-eight Gram-positive and 442 Gram-negative isolates were identified, with methicillin-susceptible Staphylococcus aureus and Escherichia coli most commonly identified. There were 2077 cases of recurrence (11.8%), with 563 cases of local recurrence, 1186 cases of distant and 25 cases which recurred both locally and distantly. Five studies investigated the association between SSI and breast cancer recurrence with three concluding that an association did exist. In conclusion, there is association between SSI and adverse cancer outcomes, but the cellular link between them remains elusive. Confounding factors of retrospective study design, surgery type and SSI definition make results challenging to compare and interpret. A standardized prospective study with appropriate statistical power is justified.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
思绪摸摸头完成签到 ,获得积分10
刚刚
研友_Lpa2On完成签到,获得积分10
刚刚
胡言完成签到,获得积分10
刚刚
糖炒栗子完成签到,获得积分10
刚刚
周周发布了新的文献求助50
1秒前
香香完成签到,获得积分10
1秒前
haorui完成签到,获得积分10
2秒前
所所应助小野采纳,获得10
2秒前
猪猪意完成签到,获得积分10
2秒前
周Z发布了新的文献求助10
2秒前
ZT完成签到,获得积分10
2秒前
快乐的小央完成签到 ,获得积分10
3秒前
直率的皮带完成签到,获得积分10
3秒前
小马甲应助jinxing采纳,获得10
4秒前
WN发布了新的文献求助10
4秒前
4秒前
5秒前
Mint发布了新的文献求助10
5秒前
搜集达人应助zzzj采纳,获得10
5秒前
6秒前
123123完成签到 ,获得积分10
6秒前
小蘑菇应助ohh采纳,获得10
6秒前
桃真心完成签到,获得积分10
7秒前
Fun完成签到,获得积分10
7秒前
斯文的如风完成签到 ,获得积分10
7秒前
平淡思雁完成签到,获得积分10
7秒前
8秒前
小巧安柏完成签到,获得积分10
8秒前
Jerry发布了新的文献求助10
9秒前
xiaoyangke发布了新的文献求助10
9秒前
LuX完成签到,获得积分10
10秒前
Chunlan完成签到,获得积分10
10秒前
科研通AI2S应助欢喜雪瑶采纳,获得10
11秒前
11秒前
ding应助高兴的世倌采纳,获得10
12秒前
Seven完成签到,获得积分20
12秒前
lebron发布了新的文献求助10
13秒前
ajiwjn完成签到,获得积分10
13秒前
Wangnono发布了新的文献求助10
13秒前
孤独尔安完成签到 ,获得积分10
14秒前
高分求助中
All the Birds of the World 3000
Weirder than Sci-fi: Speculative Practice in Art and Finance 960
IZELTABART TAPATANSINE 500
Introduction to Comparative Public Administration: Administrative Systems and Reforms in Europe: Second Edition 2nd Edition 300
Spontaneous closure of a dural arteriovenous malformation 300
Not Equal : Towards an International Law of Finance 260
Dynamics in Chinese Digital Commons: Law, Technology, and Governance 220
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3725848
求助须知:如何正确求助?哪些是违规求助? 3270880
关于积分的说明 9969512
捐赠科研通 2986307
什么是DOI,文献DOI怎么找? 1638161
邀请新用户注册赠送积分活动 777987
科研通“疑难数据库(出版商)”最低求助积分说明 747365