有机磷
内分泌系统
内科学
癌症
乳腺癌
磷酸盐
相关性
宫颈癌
生理学
化学
肿瘤科
医学
内分泌学
生物化学
生物
激素
杀虫剂
数学
农学
几何学
作者
Yanhua Liu,Yang Li,Shan‐Shan Dong,Lu Han,Ruixin Guo,Yourong Fu,Shenghu Zhang,Jianqiu Chen
标识
DOI:10.1016/j.jhazmat.2020.124020
摘要
Environmental pollution has become a concern for public health. As endocrine disruptors, organophosphate esters (OPEs) causes many diseases via human exposure. However, there is limited research on the risk of OPE exposure to female-specific cancers. Blood measurements are biomarkers for chemical exposures by their definition. Thus, in the present study, 11 OPEs were analyzed in the plasma of patients with 4 female-specific tumors. 2-Ethylhexyl diphenyl phosphate (EHDPP) was detected at the highest levels in all groups. The Spearman correlation test results showed significantly positive correlations between some OPEs in each group, which indicated that those OPEs had similar sources and/or behaved similarly in the patients of each group. However, compared with different patient groups, obvious differences in the correlation results were noted, implying the differences in the metabolism of OPEs between different groups. The results of the correlation analysis showed that EHDPP concentration was associated with the risk of breast cancer (p < 0.05), while tri-n-butyl phosphate (TNBP), tris (methylphenyl) phosphate (TMPP), triphenyl phosphate (TPHP), and EHDPP concentrations were associated with the risk of cervical cancer (p < 0.05 or p < 0.01). These findings indicated that OPEs were associated with the risk of breast and cervical cancer.
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