Role of Camellia brevistyla (Hayata) Coh. Stuart Seed Pomace Extract on Hypertension and Vascular Function in L‐NAME–Treated Mice

Abstract Camellia brevistyla (Hayata) Coh. Stuart seeds are used to produce edible oil. The seed pomace is an agricultural waste, containing approximately 8% saponin, which has antihypertensive effects. N ω ‐nitro‐L‐arginine methyl ester (L‐NAME) can induce hypertension with no deficiency on mice. Here, we investigated the effects of ethanol extract from C. brevistyla seed pomace (CBPE) in L‐NAME–induced hypertension mice. The results showed that all doses of CBPE significantly decreased systolic (117 ± 5–122 ± 5 mmHg) and diastolic (72 ± 16–77 ± 8 mmHg) blood pressure, aortic intima media thickness (48 ± 5–53 ± 5 µm), and also reduced the MDA adduct and protein carbonyl levels in the liver (101 ± 19–114 ± 17 ρmol/mL and 4.8 – 5.2 nmol/mg) compared to those observed in the L‐NAME group (140 ± 3 and 95 ± 8 mmHg, 65 ± 10 µm, 145 ± 25 ρmol/mL, and 7.8 nmol/mg; P < 0.05). These results suggest that CBPE has profitable antihypertensive properties which are preventing aorta remodeling and reducing liver oxidative stress in hypertensive mice.