A Neuroimaging Marker Based on Diffusion Tensor Imaging and Cognitive Impairment Due to Cerebral White Matter Lesions

高强度 蒙特利尔认知评估 磁共振弥散成像 认知 磁共振成像 神经心理学 神经影像学 医学 心脏病学 白质 内科学 心理学 听力学 认知障碍 精神科 放射科
作者
Na Wei,Yiming Deng,Li Yao,Weili Jia,Li Wang,Qingli Shi,Hongyan Chen,Yuesong Pan,Hongyi Yan,Yumei Zhang,Yongjun Wang
出处
期刊:Frontiers in Neurology [Frontiers Media]
卷期号:10 被引量:45
标识
DOI:10.3389/fneur.2019.00081
摘要

Background: The peak width of skeletonized mean diffusivity (PSMD) is a new, fully automated, robust imaging marker for cerebral small vessel disease (SVD), strongly associated with processing speed. However, it has never been applied to cerebral white matter lesions (WMLs). Our study aimed to investigate the correlation between PSMD and cognition, particularly in the executive function of patients with WMLs. Methods: A total of 111 WML patients and 50 healthy controls (HCs) were enrolled, and their demographic information and cardiovascular disease risk factors were recorded. Subjects were divided into three groups: WMLs with normal cognition (WMLs-NC), WMLs with vascular cognitive impairment (WMLs-VCI), and HCs. They underwent conventional head magnetic resonance imaging and diffusion tensor imaging (DTI), followed by neuropsychological and psychological examinations, including the Montreal Cognitive Assessment (MoCA), and the executive function tests. We compared executive function and PSMD among the three groups and analyzed the correlation between PSMD and cognitive function in all subjects. Results: There were no significant differences in demographic characteristics (age, sex, education level, and cardiovascular disease risk factors) among the three groups (P > 0.05), but there were significant differences in global cognition (P < 0.0001), executive function (P < 0.0001), and PSMD (P < 0.0001). The average PSMD value (×10-4 mm2/s) was 2.40 ± 0.23, 2.68 ± 0.30, and 4.51 ± 0.39 in the HC, WMLs-NC, and WMLs-VCI groups, respectively. There was no correlation between PSMD and cognition in the HC group, but PSMD was significantly correlated with MoCA scores (r = -0.3785, P < 0.0001) and executive function (r = -0.4744, P < 0.0001) in the WMLs-NC group and in the WMLs-VCI group (r = -0.4448, P < 0.0001 and r = -0.6279, P < 0.0001, respectively). Conclusions: WML patients have higher PSMD and worse cognitive performance than HCs, and PSMD is strongly associated with global cognition and executive functions in WML patients. This result provides new insights into the pathophysiology of cognitive impairment in WML patients. PSMD could be a surrogate marker for disease progression and could thus be used in therapeutic trials involving WML patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Qionglin完成签到,获得积分10
1秒前
Bao完成签到 ,获得积分10
2秒前
2秒前
初夏微凉发布了新的文献求助30
2秒前
3秒前
书霂完成签到,获得积分10
3秒前
优秀含羞草完成签到,获得积分10
4秒前
宓沂完成签到,获得积分10
4秒前
vivre223完成签到,获得积分10
4秒前
量子星尘发布了新的文献求助10
5秒前
受伤凌蝶完成签到,获得积分10
6秒前
wenjiejiang完成签到,获得积分10
7秒前
7秒前
zly完成签到 ,获得积分10
8秒前
8秒前
李某人完成签到,获得积分10
8秒前
9秒前
小鱼完成签到,获得积分10
10秒前
小崽总完成签到,获得积分10
10秒前
挽风完成签到,获得积分10
13秒前
13秒前
dxs发布了新的文献求助10
13秒前
苹果沛柔完成签到,获得积分10
14秒前
111完成签到 ,获得积分10
14秒前
Amon完成签到 ,获得积分10
15秒前
结实寄柔完成签到,获得积分10
16秒前
dh完成签到,获得积分0
16秒前
超帅鸭子发布了新的文献求助10
17秒前
苹果沛柔发布了新的文献求助10
18秒前
20秒前
sure完成签到 ,获得积分10
22秒前
伶俐的不尤完成签到,获得积分10
22秒前
可乐完成签到,获得积分10
23秒前
乐乐乐乐乐乐应助scinature采纳,获得10
25秒前
angrymax完成签到,获得积分10
26秒前
俭朴的天薇完成签到,获得积分10
27秒前
Tanhm完成签到,获得积分10
29秒前
leolin完成签到,获得积分10
29秒前
29秒前
Dr-Luo完成签到 ,获得积分10
29秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029