A Neuroimaging Marker Based on Diffusion Tensor Imaging and Cognitive Impairment Due to Cerebral White Matter Lesions

高强度 蒙特利尔认知评估 磁共振弥散成像 认知 磁共振成像 神经心理学 神经影像学 医学 心脏病学 白质 内科学 心理学 听力学 认知障碍 精神科 放射科
作者
Na Wei,Yiming Deng,Li Yao,Weili Jia,Li Wang,Qingli Shi,Hongyan Chen,Yuesong Pan,Hongyi Yan,Yumei Zhang,Yongjun Wang
出处
期刊:Frontiers in Neurology [Frontiers Media]
卷期号:10 被引量:45
标识
DOI:10.3389/fneur.2019.00081
摘要

Background: The peak width of skeletonized mean diffusivity (PSMD) is a new, fully automated, robust imaging marker for cerebral small vessel disease (SVD), strongly associated with processing speed. However, it has never been applied to cerebral white matter lesions (WMLs). Our study aimed to investigate the correlation between PSMD and cognition, particularly in the executive function of patients with WMLs. Methods: A total of 111 WML patients and 50 healthy controls (HCs) were enrolled, and their demographic information and cardiovascular disease risk factors were recorded. Subjects were divided into three groups: WMLs with normal cognition (WMLs-NC), WMLs with vascular cognitive impairment (WMLs-VCI), and HCs. They underwent conventional head magnetic resonance imaging and diffusion tensor imaging (DTI), followed by neuropsychological and psychological examinations, including the Montreal Cognitive Assessment (MoCA), and the executive function tests. We compared executive function and PSMD among the three groups and analyzed the correlation between PSMD and cognitive function in all subjects. Results: There were no significant differences in demographic characteristics (age, sex, education level, and cardiovascular disease risk factors) among the three groups (P > 0.05), but there were significant differences in global cognition (P < 0.0001), executive function (P < 0.0001), and PSMD (P < 0.0001). The average PSMD value (×10-4 mm2/s) was 2.40 ± 0.23, 2.68 ± 0.30, and 4.51 ± 0.39 in the HC, WMLs-NC, and WMLs-VCI groups, respectively. There was no correlation between PSMD and cognition in the HC group, but PSMD was significantly correlated with MoCA scores (r = -0.3785, P < 0.0001) and executive function (r = -0.4744, P < 0.0001) in the WMLs-NC group and in the WMLs-VCI group (r = -0.4448, P < 0.0001 and r = -0.6279, P < 0.0001, respectively). Conclusions: WML patients have higher PSMD and worse cognitive performance than HCs, and PSMD is strongly associated with global cognition and executive functions in WML patients. This result provides new insights into the pathophysiology of cognitive impairment in WML patients. PSMD could be a surrogate marker for disease progression and could thus be used in therapeutic trials involving WML patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
自觉秋完成签到,获得积分10
1秒前
顾矜应助007采纳,获得10
1秒前
今后应助寒冷的咖啡采纳,获得10
1秒前
上官若男应助xyz采纳,获得10
2秒前
风起枫落完成签到,获得积分10
2秒前
2秒前
2秒前
夕颜完成签到,获得积分10
3秒前
李健的小迷弟应助魏少爷采纳,获得10
3秒前
羊羊杨发布了新的文献求助10
3秒前
啊啊发布了新的文献求助10
3秒前
3秒前
Ppp发布了新的文献求助10
3秒前
zd发布了新的文献求助10
3秒前
陈念完成签到,获得积分10
4秒前
5秒前
哈哈王发布了新的文献求助10
7秒前
7秒前
7秒前
8秒前
9秒前
自由的半蕾完成签到,获得积分10
9秒前
pp63应助科研通管家采纳,获得100
10秒前
大模型应助科研通管家采纳,获得10
10秒前
10秒前
传奇3应助科研通管家采纳,获得10
10秒前
科研通AI2S应助科研通管家采纳,获得10
10秒前
情怀应助科研通管家采纳,获得10
10秒前
YamDaamCaa应助科研通管家采纳,获得30
10秒前
慕青应助科研通管家采纳,获得10
10秒前
YamDaamCaa应助科研通管家采纳,获得30
10秒前
10秒前
sisyphus_yy发布了新的文献求助10
10秒前
11秒前
挺萌的小龙虾完成签到,获得积分10
12秒前
一个爱吃爱睡的团子完成签到,获得积分10
12秒前
活力书包完成签到 ,获得积分10
12秒前
12秒前
undeaddl1发布了新的文献求助10
12秒前
科研通AI2S应助斗牛的番茄采纳,获得10
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975755
求助须知:如何正确求助?哪些是违规求助? 3520108
关于积分的说明 11200829
捐赠科研通 3256492
什么是DOI,文献DOI怎么找? 1798298
邀请新用户注册赠送积分活动 877509
科研通“疑难数据库(出版商)”最低求助积分说明 806403