表观遗传学
生物
DNA甲基化
甲基化
癌症
计算生物学
生物标志物
发起人
基因
生物标志物发现
癌症研究
遗传学
生物信息学
基因表达
蛋白质组学
作者
Yunzhen Wei,Siyao Dong,Yanjiao Zhu,Yichuan Zhao,Cheng Wu,Yuxia Zhu,Kun Li,Yan Xu
出处
期刊:Epigenomics
[Future Medicine]
日期:2019-07-26
卷期号:11 (10): 1177-1190
被引量:3
标识
DOI:10.2217/epi-2018-0138
摘要
Aim: The potential functions and prognostic value of lincRNAs with co-methylation events are explored in 9 cancer types. Materials & methods: Here, we evaluated the co-methylation events in promoter and gene-body regions between two lincRNAs across 9 cancer types by constructing a systematic biological framework. Results: The co-methylation events in both promoter and gene-body regions tended to be highly cancer specific. Patient samples could be separated by tumor and normal types according to the eigengenes of universal co-methylation clusters. Functional enrichment results revealed the lincRNAs that brought promoter and gene-body co-methylation events that affected cancer progress through participating in different pathways and could serve as potential prognostic biomarkers. Conclusion: The study provides new insight into the epigenetic regulation in cancer and leads to a potential new direction for epigenetic biomarker discovery.
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