Pembrolizumab Plus Chemotherapy in Patients With Previously Untreated Metastatic Non–small Cell Lung Cancer Without EGFR or ALK Mutations is Superior to Chemotherapy Alone

Synopsis: In this double-blind, phase 3 trial, the addition of pembrolizumab to standard chemotherapy with a platinum-based drug and pemetrexed resulted in better overall survival, progression-free survival, as well as tumor response rate among patients with previously untreated metastatic nonsquamous, non–small cell lung cancer without sensitizing epidermal growth factor receptor or anaplastic lymphoma kinase mutations. Source: Leena Gandhi, Delvys Rodriguez-Abreu, Shirish Gadgeel, et al. Pembrolizumab plus chemotherapy in metastatic non–small cell lung cancer. New England Journal of Medicine. 2018. Doi:10.1056/NEJMoa1801005.