医学
非酒精性脂肪肝
预期寿命
疾病
脂肪肝
脂肪变性
入射(几何)
肝病
重症监护医学
内科学
环境卫生
人口
光学
物理
作者
Nitin Kapoor,Jennifer Audsley,Priscilla Rupali,Joe Sasadeusz,Thomas Vizhalil Paul,Nihal Thomas,Sharon R. Lewin
出处
期刊:AIDS
[Ovid Technologies (Wolters Kluwer)]
日期:2019-06-01
卷期号:33 (7): 1105-1115
被引量:20
标识
DOI:10.1097/qad.0000000000002161
摘要
Despite the decreasing total incidence of liver-related deaths, liver disease remains one of the major non-AIDS causes of morbidity and mortality amongst people living with HIV, and a significant proportion of liver disease in these individuals can be attributed to nonalcoholic fatty liver disease (NAFLD). NAFLD in HIV infection is a growing problem in view of increasing life expectancy associated with the use of effective antiretroviral therapy (ART), wider uptake of ART and increasing rates of obesity in many Asian as well as western countries. The problem may be more pronounced in developing countries where there are limited resources available for mass screening and diagnosis of NAFLD. There is a small but growing body of literature examining NAFLD in the setting of HIV, with data from low and middle-income countries (LMICs) particularly lacking. Here, we review the cohort data on NAFLD in HIV, and discuss the risk factors, pathogenesis of hepatic steatosis, NAFLD and nonalcoholic steatohepatitis (NASH), diagnostic approaches and therapeutic options available for NAFLD in the setting of HIV, and the specific challenges of NAFLD in HIV for LMICs.
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