A Recent Progress for the Synthesis of Thiocarboxylates

Abstract As a common and integral feature of many natural products, thiocarboxylates play an important role in biologically or pharmaceutically active compounds. Thiocarboxylates often show unique physiological activities in biology and drugs, which inspires many new therapeutic drugs. The related research and developments in thioester‐based medicinal chemistry have been a rapidly developing and increasingly active topic in the last two decades. In this review, we will summarize the main methods for the synthesis of thiocarboxylates, which might provide general ideas to access more effective thioester‐based drugs.