Insights of upregulating of DDAH2 expression by pharmacological action

Recently, we have read with great interest the published paper by Sara et al [1] in Sara et al.'s study,they found the association of dimethylarginine dimethylaminohydrolase(DDAH)with atherosclerosis in rabbits,indicating that DDAH played a critical role in atherosclerosis.They found upregulation of DDAH expression by gene delivery of DDAH2 to the damaged vascular wall was a beneficially therapeutic target in the treatment of atherosclerosis.However,there are no effective drugs for upregulating DDAH2 activity.