吲唑
试剂
化学
组合化学
区域选择性
功能群
基质(水族馆)
苯
药物化学
有机化学
催化作用
海洋学
地质学
聚合物
作者
Suvam Bhattacharjee,Sudip Laru,Alakananda Hajra
摘要
A new, efficient, and metal-free protocol has been developed for remote difunctionalization of unreactive C-H bonds at the benzene core of 2H-indazole by employing Koser's reagents, which act as both sulfonyloxylating and iodinating agents under ambient air. The present methodology represents facile access to C-4-sulfonyloxylated and C-7-iodinated 2H-indazole derivatives with high regioselectivity, wide functional group tolerance, and broad substrate scope in good to excellent yields. The formed 4,7 disubstituted 2H-indazoles are the precursors of various C-4,7-functionalized 2H-indazoles through simple transformations.
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