Respiratory data management includes all the operations and provisions that ensure secure and unambiguous persistent storage and exchange of all the information that pertains to the respiratory function of an individual. Failure of the health data management framework negatively impacts the quality of the provided health-care services in several aspects. Proper design of the system and modeling of the data can reduce the probability of adverse events and enhance security, data safety, maintainability, and sustainability of the system. In this chapter, a set of modern technologies and practices are discussed along with the leading standards and regulation that pertain to the health data management.