Structures of EBI2 shed light on the treatment of autoimmune diseases

Oxysterol receptor EBI2 regulates immune responses that mediate the migration of B and T cells and stimulate antibody production. In this issue of Structure, Chen and colleagues present two cryo-EM structures of EBI2 in the inactive and active states that reveal the molecular mechanisms of EBI2 ligand binding and signaling. Oxysterol receptor EBI2 regulates immune responses that mediate the migration of B and T cells and stimulate antibody production. In this issue of Structure, Chen and colleagues present two cryo-EM structures of EBI2 in the inactive and active states that reveal the molecular mechanisms of EBI2 ligand binding and signaling. Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune responseChen et al.StructureMay 9, 2022In BriefChen et al. report cryo-EM structures of oxysterol receptor EBI2 in inactive and activated signaling states, which suggests that TM4 and TM5 function as an entry site for oxysterol ligands. Structural and functional analysis provides insight into the key residues involved in ligand recognition and Gi protein coupling. Full-Text PDF