替莫唑胺
上睑下垂
细胞凋亡
程序性细胞死亡
癌症研究
化疗
U87型
脂质体
下调和上调
化学
材料科学
胶质母细胞瘤
医学
纳米技术
内科学
生物化学
基因
作者
Jingqing Yao,Xiaobing Feng,Xinyu Dai,Gang Peng,Zhirui Guo,Zhengxia Liu,Min Wang,Wei Guo,Peng Zhang,Yuntao Li
标识
DOI:10.1016/j.nano.2022.102554
摘要
Glioblastoma (GBM) is the most fatal and common type of primary malignant tumors in central nervous system. Chemotherapy drugs are difficult to reach the encephalic region effectively due to blood-brain barrier (BBB), but functional nanoparticle drug carriers can help to solve the problem. Herein, we developed a controllable drug carrier called temozolomide magnetic temperature-sensitive liposomes (TMZ/Fe-TSL) to investigate its feasibility and molecular mechanisms on GBM. Our research found TMZ/Fe-TSL exposed to alternating magnetic field (AMF) could induce significantly GBM cell death and promote the production of ROS. It also showed that the expression of NLRP3, CASP1 and N-GSDMD was upregulated compared to the control group, while the expression of CASP3 showed a reverse change. The results indicated that TMZ/Fe-TSL exposed to the AMF was capable of inducing GBM cells death. And the way and mechanisms of cell death may involve in ROS and pyroptosis, but not apoptosis.
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